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Postnatal decline of maternally acquired rubella antibodies

Published online by Cambridge University Press:  15 May 2009

M. J. Cloonan ,
R. A. Hawkes  and
L. H. Stevens
M. J. Cloonan
Affiliation:
Virology Section, Department of Pathology, the Prince Henry Hospital, N.S.W., Australia, and the Department of Paediatrics, the Prince of Wales Hospital, N.S.W., Australia
R. A. Hawkes
Affiliation:
Virology Section, Department of Pathology, the Prince Henry Hospital, N.S.W., Australia, and the Department of Paediatrics, the Prince of Wales Hospital, N.S.W., Australia
L. H. Stevens
Affiliation:
Virology Section, Department of Pathology, the Prince Henry Hospital, N.S.W., Australia, and the Department of Paediatrics, the Prince of Wales Hospital, N.S.W., Australia
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The postnatal decline of maternally acquired rubella antibody was studied in a large group of infants. A high degree of variability was found in the rate of antibody decline (half-life). Ninety-two babies had rubella antibody half-lives lying between 14 and 70 days and three had values considerably higher. There was no significant difference between the rubella antibody half-lives of the sexes. The antibody titre at birth was weakly correlated with both birth weight and gestational age. There was a highly significant positive correlation between the baby's antibody titre at birth and that of its mother. There was a positive relationship between the half-life and the persistence of rubella antibody. Some babies had no detectable antibody by 2 months whereas others still possessed antibody at 9 months. It was found that the relationship between the half-life and the rubella antibody titre at or near birth could be described by a rectangular hyperbola.

Type
Research Article
Information
Journal of Hygiene , Volume 68 , Issue 3 , September 1970 , pp. 461 - 468
Copyright
Copyright © Cambridge University Press 1970

References

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