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The postnatal acquisition of factors which affect the influenza haemagglutination-inhibition test

Published online by Cambridge University Press:  25 March 2010

P. C. A. Grint ,
S. Argent  and
R. B. Heath
P. C. A. Grint
Affiliation:
Virology Department, St Bartholomew's Hospital, West Smithfield, London, EC1A 7BE
S. Argent
Affiliation:
Virology Department, St Bartholomew's Hospital, West Smithfield, London, EC1A 7BE
R. B. Heath
Affiliation:
Virology Department, St Bartholomew's Hospital, West Smithfield, London, EC1A 7BE
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Summary

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Levels of maternally transferred antibodies against the surface antigen of the A/Texas/1/77 strain of influenza virus showed the expected decline during infancy when measured by complement fixation (CF). However, this decline was not observed when these antibodies were measured by haemagglutination-inhibition (HI). It has been postulated that this discrepancy is due to the acquisition, in the early days of life, of non-specific serum factors which increase the HI activity of sera. The levels of these factors were determined indirectly by calculating HI: CF ratios and it was shown that the factors are rapidly acquired by children between the fifth and twentieth week of life.

Type
Research Article
Information
Journal of Hygiene , Volume 89 , Issue 2 , October 1982 , pp. 329 - 334
Copyright
Copyright © Cambridge University Press 1982

References

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