Hostname: page-component-76fb5796d-25wd4 Total loading time: 0 Render date: 2024-04-26T07:11:29.690Z Has data issue: false hasContentIssue false
  • English
  • Français

Pattern of antibiotic and heavy-metal ion resistance in recent hospital isolates of Staphylococcus aureus

Published online by Cambridge University Press:  19 October 2009

M. R. Millar ,
N. Griffin  and
N. Keyworth
M. R. Millar
Affiliation:
Departments of Medical Microbiology and Pathology, Leeds General Infirmary
N. Griffin
Affiliation:
Departments of Medical Microbiology and Pathology, Leeds General Infirmary
N. Keyworth
Affiliation:
Departments of Medical Microbiology and Pathology, Leeds General Infirmary
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Two hundred and one strains of Staphylococcus aureus isolated from in-patients and out-patients were examined for sensitivity to antibiotics, heavy-metal ions and ethidium bromide and for phage-typing pattern.

Heavy-metal ion resistance was less frequent than reported in previous studies and was as frequent in penicillinase non-producing as producing strains. ‘Methicillin-resistant’ strains were resistance to ethidium bromide and mercury. Resistance to heavy-metal ions, including cadmium, may bo becoming less common amongst clinical isolates of S. aureus.

Type
Research Article
Information
Epidemiology & Infection , Volume 99 , Issue 2 , October 1987 , pp. 343 - 347
Copyright
Copyright © Cambridge University Press 1987

References

REFERENCES

Blair, J. E. & Williams, R. E. O. (1961). Phage typing of staphylococci. Bulletin of the World Health Organisation 24, 771–784.Google ScholarPubMed
Cowan, S. T. (1938). The classification of staphylococci by precipitation and biological reactions. Journal of Pathology and Bacteriology 46, 31–45.CrossRefGoogle Scholar
DiSalvo, J. W. (1958). Deoxyribonuclease and congulase activity of micrococci. United Stales Armed Forces Medical Journal, Technical Bulletin 9, 101–100.Google ScholarPubMed
Dyke, K. G. H., Parker, M. T. & Richmond, M. H. (1970) Penicillinase production and metalion resistance in Staphylococcus aureus cultures isolated from hospital patients. Journal of Medical Microbiology 3, 125–136.CrossRefGoogle ScholarPubMed
Grubb, W. B., Townsend, D. E., Greed, L. C., Ashdown, M. & Momoh, M. (1983). Characteristics of methicillin-resistant Staphylococcus aureus endemic in Australian hospitals. In Proceedings of the 13th International Congress of Chemotherapy, Vienna (eds Spitzy, K. H., Karrer, K.), 23–26.Google Scholar
Jevons, M. P. (1961). ‘Celbenin’ resistant staphylococci. British Medical Journal 1, 124–125.CrossRefGoogle Scholar
Kondo, I., Ishikawa, T. & Nakahara, H. (1974). Mercury and cadmium resistances mediated by the penicillinase plasmid in Staphylococcus aureus. Journal of Bacteriology 117, 1–7.CrossRefGoogle ScholarPubMed
Lewis, G. P., Jusko, W. J., & Caughlin, L. L. (1972). Contribution of eigarette smoking to cadmium accumulation in man. Lancet i, 291–292.CrossRefGoogle Scholar
Nakahara, H., Ishikawa, T., Sarai, Y. & Kondo, I. (1977). Distribution of resistances to metals and antibiotics of staphylococcal strains in Japan. Zentralblatt für Bakleriologie A 237, 470–476.Google ScholarPubMed
Nandi, M., Slone, D., Jick, M., Shapiro, S. & Lewis, G. P. (1969). The cadmium content of cigarettes. Lancet ii, 1320–30.Google Scholar
Novick, R. P. & Roth, C. (1968). Plasmid-linked resistance to inorganic salts in Staphylococcus aureus. Journal of Bacteriology 95, 1335–1342.CrossRefGoogle ScholarPubMed
Novick, R. P., Murphy, E., Grycan, T. J., Baron, E. & Edelman, I. (1979). Penicillinase plasmids of Staphylococcus aureus: restriction-deletion maps. Plasmid 2, 109–129.CrossRefGoogle ScholarPubMed
Richmond, M. H. & John, M. (1964). Co-transduction by a staphylococcal phage of the genes responsible for penicillinase synthesis and resistance to mercury salts. Nature 202, 1360.CrossRefGoogle ScholarPubMed
Rosdahl, V. T. & Rosendal, K. (1980). Resistance to cadmium, arsenato and mercury among Danish strains of Staphylococcus aureus isolated from cases of bacteraemia, 1957–74. Journal of Medical Microbiology 13, 383–391.CrossRefGoogle Scholar
Schroeder, H. A., Balassa, J. J. & Hogencamp, J. C. (1961). Abnormal trace metals: cadmium. Journal of Chronic Diseases 14, 236–258.CrossRefGoogle Scholar
Shalita, Z., Murphy, E. & Novick, R. P. (1980). Penicillinase plasmids of Staphylococcus aureus: Structural and evolutionary relationships Plasmid 3, 291–311.CrossRefGoogle ScholarPubMed
Stokes, E. J. & Ridgway, G. L. (1980). Clinical Bacteriology, 5th edition. London: Arnold.Google Scholar
Townsend, D. E., Ashdown, N., & Grubb, W. B. (1985). Evolution of Australian isolates of methicillin-resistant Staphylococcus aureus: a problem of plasmid incompatibility? Journal of Medical Microbiology 20, 49–61.CrossRefGoogle ScholarPubMed
Townsend, D. E., Ashdown, N., Bolton, S., Bradley, S., Duckworth, G., Moorhouse, E. C. & Grubb, W. B. (1987). The international spread of methicillin-resistant Staphylococcus aureus. Journal of Hospital Infection 9, 60–71.CrossRefGoogle ScholarPubMed