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Patient and strain characteristics in relation to the outcome of meningococcal disease: a multivariate analysis

Published online by Cambridge University Press:  15 May 2009

R. J. P. M. Scholten ,
H. A. Bijlmer ,
H. A. Valkenburg  and
J. Dankert
R. J. P. M. Scholten
Affiliation:
Institute for Research in Extramural Medicine, Vrije Universiteit, Van der Boechorststraat 7. 1081 BT, Amsterdam, The Netherlands Netherlands Reference Laboratory for Bacterial Meningitis, WHO Collaborating Centre, University of Amsterdam/National Institute for Public Health and Environmental Protection, Amsterdam, The Netherlands
H. A. Bijlmer
Affiliation:
Netherlands Reference Laboratory for Bacterial Meningitis, WHO Collaborating Centre, University of Amsterdam/National Institute for Public Health and Environmental Protection, Amsterdam, The Netherlands
H. A. Valkenburg
Affiliation:
Institute for Research in Extramural Medicine, Vrije Universiteit, Van der Boechorststraat 7. 1081 BT, Amsterdam, The Netherlands
J. Dankert
Affiliation:
Netherlands Reference Laboratory for Bacterial Meningitis, WHO Collaborating Centre, University of Amsterdam/National Institute for Public Health and Environmental Protection, Amsterdam, The Netherlands
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To investigate the joint association of patient and strain characteristics with the outcome of meningococcal disease (MD), data were collected on 563 consecutive cases of MD reported between 1989 and 1990 in The Netherlands. The meningococcal isolates were characterized with regard to their surface characteristics. Sequelae occurred in 8.5% of the patients, and were only associated with the presence of bacteraemia. The case-fatality rate was 7.7%. Infants aged ≤ 5 months and patients in the age-groups of 10–19 years and ≥ 50 years had an increased risk for a fatal outcome compared with children from 6 months to 9 years old (Odds Ratios [ORs]: 5.1, 3.4 and 9.8, respectively). The OR for females versus males was 2.3. The ORs for patients with bacteraemia, or a combination of bacteraemia and meningitis, compared with meningitic patients, were 2.3 and 3.1. Meningococcal strain characteristics did not influence the case-fatality rate substantially. In conclusion, host factors were found to be determinants for a fatal outcome of MD in The Netherlands from 1989 to 1990.

Type
Research Article
Information
Epidemiology & Infection , Volume 112 , Issue 1 , February 1994 , pp. 115 - 124
Copyright
Copyright © Cambridge University Press 1994

References

REFERENCES

Andersen, BM. Mortality in meningococcal infections. Scand J Infect Dis 1978; 10: 277–82.CrossRefGoogle ScholarPubMed
Peltola, H. Meningococcal disease: still with us. Rev Infect Dis 1983: 5: 71–91.CrossRefGoogle ScholarPubMed
Fallon, RJ.Brown, WM.Lore, W. Meningococcal infections in Scotland 1972–82. J Hyg 1984: 93: 167–80.CrossRefGoogle ScholarPubMed
de Wals, P.Hertoghe, L.Reginster, G et al. , Mortality in meningococcal disease in Belgium. J Infect 1984: 8: 264–73.CrossRefGoogle ScholarPubMed
Halstensen, A.Pedersen, SHJ.Haneberg, B, Bjorvatn, B, Solberg, CO. Case-fatality of meningococcal disease in western Norway. Scand J Infect Dis 1987: 19: 35–42.CrossRefGoogle ScholarPubMed
Spanjaard, L.Bol, P.de Marie, S.Zanen, HC. Association of meningococcal serogroups with the course of disease in the Netherlands. 1959–83. Bull WHO 1987: 65: 861–8.Google ScholarPubMed
Havens, PL.Garland, JS.Brook, MM.Dewitz, BA.Stremski, ES, Troshynski, TJ. Trends in mortality in children hospitalized with meningococcal infections. 1957 to 1987. Pediatr Infect Dis J 1989: 8: 8–11.CrossRefGoogle ScholarPubMed
Palmer, SR.Corson, J.Hall, R et al. , Meningococcal disease in Wales: clinical features, outcome and public health management. J Infect 1992: 25: 321–8.CrossRefGoogle ScholarPubMed
Samuelsson, S.Ege, P.Berthelsen, B.Lind, I. An outbreak of serogroup B:15:P1.16 meningococcal disease. Frederiksborg county. Denmark. 1987–9. Epidemiol Infect 1992; 108: 19–30.CrossRefGoogle ScholarPubMed
Spanjaard, L.Bol, P.de Marie, S, Zanen, HC. Association of meningococcal serotypes with the course of disease: serotypes 2a and 2b in the Netherlands. 1959–1981. J Infect Dis 1987; 155: 277–82.CrossRefGoogle ScholarPubMed
Abdillahi, H.Poolman, JT. Whole-cell ELISA for typing Neisseria meningitidis with monoclonal antibodies. FEMS Mibrobiol Lett 1987: 48: 367–71.CrossRefGoogle Scholar
Scholten, RJPM.Kuipers, B.Valkenburg, HA.Dankert, J.Zollinger, WD.Poolman, JT. Lipooligosaccharide immunotyping of Neisseria meningitidis by a whole-cell ELISA using monoclonal antibodies. In: Scholten, RJPM. The increased incidence of meningococcal disease in the Netherlands. 1980 1990 [thesis]. Amsterdam. The Netherlands: Vrije Universiteit. 1993:45 61.Google Scholar
Scholten, RJPM.Bijlmer, HA.Poolman, JT. et al. Meningococcal disease in the Netherlands. 1958–1990: a steady increase of the incidence since 1982 partially caused by new serotypes and subtypes of Neisseria meningitidis. Clin Infect Dis 1993; 16: 237–46.CrossRefGoogle ScholarPubMed
Slaterus, KW. Serological typing of meningococci by means of micro-precipitation. Antonie Van Leeuwenhoek 1961: 27: 305–15.CrossRefGoogle ScholarPubMed
osmer, DW.Lemeshow, S. Applied logistic regression. New York: Wiley & Sons. 1989.Google Scholar
Mims, CA. The pathogenesis of infectious disease. London: Academic Press, 1987.Google Scholar