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Pathogenesis of foot-and-mouth disease: clearance of the virus from the circulation of cattle and goats during experimental viraemia

Published online by Cambridge University Press:  15 May 2009

P. Sutmoller  and
J. W. McVicar
P. Sutmoller
Affiliation:
Plum Island Animal Disease Center, Northeastern Region, Agricultural Research Service, U.S. Department of Agriculture, P.O. Box 848, Greenport, N.Y. 11944
J. W. McVicar
Affiliation:
Plum Island Animal Disease Center, Northeastern Region, Agricultural Research Service, U.S. Department of Agriculture, P.O. Box 848, Greenport, N.Y. 11944
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Viraemia is an important aspect of the pathogenesis of infectious diseases, but the mechanisms of entry and removal of virus from the vascular system particularly in natural hosts are poorly understood. The results of this study showed that the clearance of foot and mouth disease virus (FMDV) from the circulation of cattle and goats followed the general rules for the clearance of inert particulate materials and other viruses from the circulation. High doses of infused FMDV were cleared less efficiently than low doses, probably as a result of a depletion of the reticulo-endothelial system by the higher doses. FMDV was cleared from the circulation of cattle at a considerably slower rate than from the circulation of goats, but in both species significant individual variation in clearance was observed. These results could explain individual as well as species variations relative to the onset and duration of viraemia.

Type
Research Article
Information
Journal of Hygiene , Volume 77 , Issue 2 , October 1976 , pp. 245 - 253
Copyright
Copyright © Cambridge University Press 1976

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