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On the Production of Antitoxin by the Injection of Filtrates of Cultures of Non-virulent Diphtheria Bacilli

Published online by Cambridge University Press:  15 May 2009

J. A. Arkwright
J. A. Arkwright
Affiliation:
(From the Lister Institute of Preventive Medicine.)
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We are still in doubt regarding the exact position of those bacilli which, morphologically and culturally, appear to be identical with the Klebs-Loeffler bacillus but which differ from it only in the absence of specific pathogenic power for laboratory animals. Most writers regard such non-virulent strains as true diphtheria bacilli which have lost their virulence and toxigenic power either temporarily or permanently. Others however are inclined to place them in a group allied to that of the genuine Klebs-Loeffler bacillus and express doubts as to whether they at any time possessed a claim to pathological significance (Graham Smith, 1904).

Type
Research Article
Information
Journal of Hygiene , Volume 9 , Issue 4 , December 1909 , pp. 409 - 411
Copyright
Copyright © Cambridge University Press 1909

References

REFERENCES

Arkwright, J. A. (1908). Observations on the Bacteriology of an Epidemic of Diphtheria in a School. Journ. of Hygiene, Vol. VIII. p. 48.CrossRefGoogle Scholar
Graham-Smith, G. S. (1904). A study of the virulence of Diphtheria bacilli isolated from 113 persons, etc. Journ. of Hygiene, Vol. IV. p. 258.CrossRefGoogle Scholar
Petrie, G. F. (1905). On the relationship of the Pseudo-diphtheria to the Diphtheria bacillus. Journ. of Hygiene, Vol. V. p. 134.CrossRefGoogle Scholar