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A note on the safety testing of vaccines
Published online by Cambridge University Press: 15 May 2009
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The use of the hypergeometric distribution in calculations of sample volumes for safety testing is criticized. Alternative interpretations of the concept of ‘infective ml. doses’ lead to slightly different solutions, the simplest of which, involving the exponential function, is recommended for general use.
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- Copyright © Cambridge University Press 1971
References
REFERENCES
Anderson, E. C., Capstick, P. B., Mowat, G. N. & Leech, F. B. (1970). In vitro method for safety testing of foot-and-mouth disease vaccines. Journal of Hygiene 68, 159.CrossRefGoogle ScholarPubMed
Peto, S. & Maidment, B. J. (1969). Tables of the upper limit to the estimate of the density of contaminating particles in a medium. Journal of Hygiene 67, 533.CrossRefGoogle Scholar
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