Hostname: page-component-76fb5796d-dfsvx Total loading time: 0 Render date: 2024-04-26T06:19:44.673Z Has data issue: false hasContentIssue false
  • English
  • Français

A non-lethal test of the resistance of inbred mice to herpes simplex virus type 1

Published online by Cambridge University Press:  25 March 2010

L. H. Collier  and
Q. J. Scott
L. H. Collier
Affiliation:
Department of Virology, The London Hospital Medical College, Turner Street,London El 2AD
Q. J. Scott
Affiliation:
Department of Virology, The London Hospital Medical College, Turner Street,London El 2AD
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Inbred strains of mice varying in susceptibility to intraperitoneal (i. p.) inoculation of HSV-1 were tested by inoculating 105 p.f.u. of the SC 16 strain into the ear pinna. Increase in ear thickness was less in resistant than in susceptible strains. In the resistant C57BL/6 strain, local replication of virus, spread to cervical ganglia and development of latent infections of the ganglia were all less than in susceptible DBA/2 mice; there was also less cellular infiltration of the inoculation site. Like resistance to i.p. inoculation, resistance to ear inoculation appears to be inherited as a dominant characteristic. The test provides a non-lethal method of distinguishing between resistance and susceptibility of inbred strains of mice to HSV-1 and may also be useful in defining resistance factors.

Type
Research Article
Information
Journal of Hygiene , Volume 89 , Issue 2 , October 1982 , pp. 335 - 345
Copyright
Copyright © Cambridge University Press 1982

References

REFERENCES

Dulbecco, R. & Vogt, M. (1954). Plaque formation and isolation of pure lines with poliomyelitis viruses. Journal of Experimental Medicine 99, 167–182.CrossRefGoogle ScholarPubMed
Harbour, D. A., Hill, T. J. & Blyth, W. A. (1981). Acute and recurrent herpes simplex in several strains of mice. Journal of General Virology 55, 31–40.CrossRefGoogle ScholarPubMed
Hill, T. J., Field, H. J. & Blyth, W. A. (1975). Acute and recurrent infection with herpes simplex virus in the mouse: a model for studying latency and recurrent disease. Journal of General Virology 28, 341–353.CrossRefGoogle Scholar
Lopez, C. (1975). Genetics of natural resistance to herpesvirus infections in mice. Nature 258, 152–153.CrossRefGoogle ScholarPubMed
Lopez, C. (1978). Immunological nature of genetic resistance of mice to herpes simplex virus type 1 infection. IARC Science Publications 24, 775–781.Google Scholar
Nash, A. A., Field, H. J. & Quartey-Papafio, R. (1980). Cell-mediated immunity in herpes simplex virus-infected mice: induction, characterization and antiviral effects of delayed type hypersensitivity. Journal of General Virology 48, 351–357.CrossRefGoogle ScholarPubMed
Stevens, J. G. & Cook, M. K. (1971). Latent herpes simplex virus in spinal ganglia of mice. Science, New York 173, 843–845.CrossRefGoogle ScholarPubMed
Thompson, W. R. (1947). Use of moving averages and interpolation to estimate median-effective dose. Bacteriological Reviews 11, 115–145.CrossRefGoogle ScholarPubMed