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Neutralizing antibodies against 33 human adenoviruses in normal children in Rome

  • E. D'ambrosio (a1), N. Del Grosso (a1), A. Chicca (a1) and M. Midulla (a1)

Summary

There are few data about the distribution of neutralizing antibodies (NA) against adenovirus types in the Italian population, especially the high-numbered ones. We tested the sera from 453 children and 51 young adults to evaluate NA against adenovirus prototypes 1–33. Using the microneutralization test, 338 (74·6%) of the children's sera were positive for at least one adenovirus type. Antibody to type 2 was the most frequently detected followed, in descending order, by antibody to types 5, 1 and 3. All these types are known to be associated with disease but antibody to type 7, a type also associated with disease, was less frequent than that to other serotypes such as 18 and 31, the pathogenicity of which in man is not clearly established. The antibody positivity rate rose with age for the more frequent types while it did not vary for the less frequent ones. The number of sera with NA against more than one adenovirus type increased with age. With regard to types 1–8, we found that their frequencies in Italy were similar to those found in the U.S.A.

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References

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Bell, J. A., Rowe, W. P. & Rosen, L. (1962). II. Adenoviruses American Journal of Public Health 52, 902907.
Brandt, C. D., Kim, H. W., Vargosko, A. J., Jeffries, B. C., Arrobio, J. O., Rindge, B., Parrott, R. H. & Chanock, R. M. (1969). Infections in 18,000 infants and children in a controlled study of respiratory tract disease. I. Adenovirus pathogenicity in relation to serologic type and illness syndrome. American Journal of Epidemiology 90, 484500.
Fox, J. P., Brandt, C. D., Wassermann, F. E., Hall, C. E., Spigland, I., Kogon, A. & Elveback, L. R. (1969). The virus watch program: a continuing surveillance of viral infections in metropolitan New York families. American Journal of Epidemiology 89, 2550.
Foy, H. M. & Grayston, J. T. (1976). Adenoviruses. In Viral Infections in Humans (ed. Evans, A. S.), New York: Wiley.
Jackson, G. G. & Muldoon, R. L. (1975). Viruses Causing Common Respiratory Infections in Man, p. 183. Chicago, London: University of Chicago Press.
Kasel, J. A. (1979). Adenoviruses. In Diagnostic Procedures for Viral, Rickettsial and Chlamydial infections, 5th ed. (ed. Lennette, E. H. and Schmidt, N. J.). Washington, D.C.: American Public Health Association.
Potter, C. W. & Shedden, W. I. H. (1963). The distribution of adenovirus antibodies in normal children. Journal of Hygiene 61, 155160.
Schmidt, N. J., Lennette, E. H. & King, C. J. (1966). Neutralizing, hemagglutination-inhibition and group complement-fixing antibody responses in human adenovirus infections. Journal of Immunology 97, 6474.
Sterner, G. (1962). Adenovirus infection in childhood: an epidemiological and clinical survey among Swedish children. Acta Paediatrica Scandinavica. Supplementum 142, 130.
Tai, F. H. & Grayston, J. T. (1962). Adenovirus neutralizing antibodies in persons on Taiwan. Proceedings of the Society for Experimental Biology and Medicine 109, 881884.
Taylor, P. E. (1977). Adenoviruses: diagnosis of infections. In Comparative Diagnosis of Viral Diseases (ed. Kurstak, E. and Kurstak, C.). New York: Academic Press.
Wigand, R., Gelderblom, H. & Wadell, G. (1980). New human adenovirus (candidate adenovirus 36), a novel member of subgroup D. Archives of Virology 64, 225233.

Neutralizing antibodies against 33 human adenoviruses in normal children in Rome

  • E. D'ambrosio (a1), N. Del Grosso (a1), A. Chicca (a1) and M. Midulla (a1)

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