Hostname: page-component-8448b6f56d-qsmjn Total loading time: 0 Render date: 2024-04-16T21:41:59.164Z Has data issue: false hasContentIssue false
  • English
  • Français

Neutralization kinetics studies with type SAT 2 foot-and-mouth disease virus strains:II. Antigenic differentiation of vaccine strains

Published online by Cambridge University Press:  15 May 2009

M. M. Rweyemamu ,
J. C. Booth ,
N. Parry  and
T. W. F. Pay
M. M. Rweyemamu
Affiliation:
The Wellcome Foundation Ltd, Wellcome Foot and Mouth Disease Vaccine Laboratory, Pirbright, Woking, Surrey, U.K.
J. C. Booth
Affiliation:
The Wellcome Foundation Ltd, Wellcome Foot and Mouth Disease Vaccine Laboratory, Pirbright, Woking, Surrey, U.K.
N. Parry
Affiliation:
The Wellcome Foundation Ltd, Wellcome Foot and Mouth Disease Vaccine Laboratory, Pirbright, Woking, Surrey, U.K.
T. W. F. Pay
Affiliation:
The Wellcome Foundation Ltd, Wellcome Foot and Mouth Disease Vaccine Laboratory, Pirbright, Woking, Surrey, U.K.
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

A comparison of homologous and heterologous rates of neutralization demonstrated that antigenic relationships of foot-and-mouth disease virus strains could be differentiated quantitatively by the kinetics of neutralization method described previously (Rweyemamu, Booth & Pay, 1977). Conventional formulae for r, R and D values could be applied to results obtained by this method. It was demonstrated that results analysed this way gave R values which were similar to those obtained with other neutralization test methods but which were generally smaller than those obtained with complement fixation test results. It was demonstrated that there were wide differences between the vaccine strains tested as demonstrated by R value relationships. An examination of r values, however, demonstrated that antisera to the Moz 1/70 strain were highly reactive with most of the virus strains from Central and Southern Africa. The selection of FMD virus strains with a wide serological range for vaccine production is discussed.

Type
Research Article
Information
Journal of Hygiene , Volume 78 , Issue 3 , June 1977 , pp. 429 - 438
Copyright
Copyright © Cambridge University Press 1977

References

REFERENCES

Anderson, E. C., Anderson, J. & Doughty, W. J. (1974). The foot-and-mouth disease virus subtype variants in Kenya. Journal of Hygiene 73, 237–44.CrossRefGoogle ScholarPubMed
Brooksby, J. B. (1968). Variants and Immunity: definitions for serological investigations. International Symposium on Foot-and-Mouth Disease. Variants and Immunity. Lyon 1967. Symposium Series. Immunobiological Standardization 8, 1–10.Google Scholar
Cowan, K. M. & Trautman, R. (1967). Immunochemical studies of foot-and-mouth disease. 1. Complement fixation reactions with isolated antigenic components. Journal of Immunology 99, 729–36.CrossRefGoogle Scholar
De Castro, M. P. (1964). Behaviour of the foot-and-mouth disease virus in cell cultures: susceptibility of the IB-RS-2 cell line. Archivos do Instituto Biologico, São Paulo 31, 63.Google Scholar
Forman, A. J. (1974). A study of foot-and-mouth disease virus strains by complement fixation. 1. A model for the fixation of complement by antigen/antibody mixtures. Journal of Hygiene 72, 397–405.CrossRefGoogle Scholar
Forman, A. J. (1975). The subtype classification of strains of foot-and-mouth disease virus. Journal of Hygiene 74, 227–32.CrossRefGoogle ScholarPubMed
Martin, W. B. & Chapman, W. G. (1961). The tissue culture colour test for assaying the virus and neutralizing antibody of foot-and-mouth disease and its application to the measurements of immunity in cattle. Research in Veterinary Science 2, 53–61.CrossRefGoogle Scholar
Pay, T. W. F. & Schermbrucker, C. G. (1974). Production of foot-and-mouth disease vaccines against various virus types and subtypes. Bulletin. Office international des Épizooties 81, 1261–70.Google Scholar
Pereira, H. G. P. (1976). Subtyping of foot-and-mouth disease virus. A paper presented at the International Symposium on Foot-and-Mouth Disease.International Association of Biological Standardization,Lyon,1976.Google Scholar
Rweyemamu, M. M., Booth, J. C. & Pay, T. W. F. (1977). Neutralization kinetics studies with type SAT 2 foot-and-mouth disease virus strains. I. Factors that influence the rate and pattern of neutralization. Journal of Hygiene 78, 99–112.CrossRefGoogle ScholarPubMed
Rweyemamu, M. M., Pay, T. W. F. & Parker, M. J. (1976). Serological differentiation of foot-and-mouth disease virus strains in relation to selection of suitable vaccine viruses. A paper presented at the International Symposium on Foot and-Mouth Disease.International Association of Biological Standardization.Lyon,1976.Google Scholar
Stellman, C., Moreau, Y. & Roumiantzeff, M. (1972). Biomathematical system of relation-ship and dominance for the classification of foot-and-mouth disease strains. Archiv für die gesamte Virusforschung 37, 357–64.CrossRefGoogle Scholar