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Necrobacillosis and immunity in mice

Published online by Cambridge University Press:  15 May 2009

G. R. Smith ,
L. M. Wallace  and
D. Till
G. R. Smith
Affiliation:
Nuffield Laboratories of Comparative Medicine, Institute of Zoology, The Zoological Society of London, Regent's Park, London NW1 4RY
L. M. Wallace
Affiliation:
Nuffield Laboratories of Comparative Medicine, Institute of Zoology, The Zoological Society of London, Regent's Park, London NW1 4RY
D. Till
Affiliation:
Nuffield Laboratories of Comparative Medicine, Institute of Zoology, The Zoological Society of London, Regent's Park, London NW1 4RY
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Summary

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The study arose from the recent finding that sub-lethal numbers of certain bacterial species greatly enhanced the infectivity of Fusobacterium necrophorum.

A severe F. necrophorum infection in mice, cured with metronidazole, produced significant though slight resistance, which was demonstrable by challenge with a minute dose of F. necrophorum (< 20 organisms) suspended in a sub-lethal dose of Escherichia coli (300 × 10 organisms) to enhance fusobacterial infectivity. In an earlier comparable experiment, challenge with F. necrophorum alone, in necessarily large doses (≥3 × lO organisms), failed to demonstrate that a single cured fusobacterial infection gave rise to resistance; such an infection neither protected against the fatal necrobacillosis produced by challenge nor prolonged survival.

A sub-lethal E. coli infection was also shown by challenge with a minute dose of F. necrophorum (< 10 organisms), suspended in a sub-lethal dose of E. coli (152 × 10 organisms), to produce significant though slight protection against necrobacillosis.

The degrees of resistance demonstrated were too slight to give any encouragement to the prospect of an effective necrobacillosis vaccine.

Type
Special Article
Information
Epidemiology & Infection , Volume 103 , Issue 1 , August 1989 , pp. 211 - 215
Copyright
Copyright © Cambridge University Press 1989

References

REFERENCES

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