Molecular epidemiology of Norovirus strains circulating in Ireland from 2003 to 2004

A. WATERS; S. COUGHLAN; L. DUNFORD; W. W. HALL

doi:10.1017/S0950268806006121

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Since 2002, the burden of norovirus (NoV) infection in Ireland has increased. Outbreaks in institutional settings are the most common causing widespread disruption to health service delivery. This is the first national study of NoV in the Republic of Ireland and its aim was to identify the major NoV strains circulating in Ireland over a 13-month period between November 2003 and November 2004, inclusive. A prospective study screened faecal samples (n=478) for NoV RNA. Positive samples (n=116) were further analysed by a second PCR, targeted to the orf1/orf2 junction of the virus. Phylogenetic analysis was based on sequence alignments of this domain. GII/4 viruses represented 92·2% of sequences, 2·7% were GII/2, GII/3 and GGIIB cluster-like strains. The remaining 5·2% were of GI origin. NoV was detectable throughout the study period, although two peaks of infection were observed. The majority of infections were caused by a range of closely related GII/4 NoV strains.

Crossref Citations

This article has been cited by the following publications. This list is generated based on data provided by Crossref.

Logan, Catriona O’Leary, John J. and O'Sullivan, Niamh 2007. Real-time reverse transcription PCR detection of norovirus, sapovirus and astrovirus as causative agents of acute viral gastroenteritis. Journal of Virological Methods, Vol. 146, Issue. 1-2, p. 36.

Tan, Ming and Jiang, Xi 2007. Norovirus–host interaction: implications for disease control and prevention. Expert Reviews in Molecular Medicine, Vol. 9, Issue. 19, p. 1.

Waters, Allison Coughlan, Suzie and Hall, William W. 2007. Characterisation of a novel recombination event in the norovirus polymerase gene. Virology, Vol. 363, Issue. 1, p. 11.

Victoria, Matías Carvalho-Costa, Filipe Aníbal Heinemann, Marcos Bryan Leite, José Paulo and Miagostovich, Marize 2007. Prevalence and Molecular Epidemiology of Noroviruses in Hospitalized Children With Acute Gastroenteritis in Rio de Janeiro, Brazil, 2004. Pediatric Infectious Disease Journal, Vol. 26, Issue. 7, p. 602.

Nayak, Mukti K. Balasubramanian, Ganesh Sahoo, Ganesh C. Bhattacharya, Rittwika Vinje, Jan Kobayashi, Nobumichi Sarkar, Mamta Chawla Bhattacharya, Mihir K. and Krishnan, Triveni 2008. Detection of a novel intergenogroup recombinant Norovirus from Kolkata, India. Virology, Vol. 377, Issue. 1, p. 117.

Waters, Allison Dunford, Linda Tuite, Gráinne Connell, Jeff Dooley, Séamus Foley, Barbara McKeown, Paul Hall, William W and Coughlan, Suzie 2008. Significant Prevalence and Genetic Diversity of Norovirus Infection in Irish Children. Pediatric Research, Vol. 64, Issue. 3, p. 312.

KELLY, S. FOLEY, B. DUNFORD, L. COUGHLAN, S. TUITE, G. DUFFY, M. MITCHELL, S. SMYTH, B. O'NEILL, H. McKEOWN, P. HALL, W. and LYNCH, M. 2008. Establishment of a national database to link epidemiological and molecular data from norovirus outbreaks in Ireland. Epidemiology and Infection, Vol. 136, Issue. 11, p. 1472.

Logan, Catriona and O‘Sullivan, Niamh 2008. Detection of Viral Agents of Gastroenteritis: Norovirus , Sapovirus and Astrovirus . Future Virology, Vol. 3, Issue. 1, p. 61.

Donaldson, Eric F. Lindesmith, Lisa C. Lobue, Anna D. and Baric, Ralph S. 2008. Norovirus pathogenesis: mechanisms of persistence and immune evasion in human populations. Immunological Reviews, Vol. 225, Issue. 1, p. 190.

Hwang, Pil-Joo Kwak, Ji Hee Lee, Taek Jin and Jeong, Su Jin 2009. Clinical features of acute noroviral gastroenteritis in children : comparison with rotaviral gastroenteritis. Korean Journal of Pediatrics, Vol. 52, Issue. 4, p. 453.

Arias, C. Sala, M.R. Domínguez, A. Torner, N. Ruíz, L. Martínez, A. Bartolomé, R. de Simón, M. and Buesa, J. 2010. Epidemiological and clinical features of norovirus gastroenteritis in outbreaks: a population-based study. Clinical Microbiology and Infection, Vol. 16, Issue. 1, p. 39.

Hartnell, R. Lowther, J. Avant, J. Dancer, D. Lees, D. and Russell, J. 2012. The development of LENTICULES™ as reference materials for noroviruses. Journal of Applied Microbiology, Vol. 112, Issue. 2, p. 338.

Lennon, G. Reidy, N. Collins, P. J. Gunn, L. Coyle, P. V. Cryan, B. Fanning, S. and O’Shea, H. 2014. A comparison of the efficiency of ELISA and selected primer sets to detect Norovirus isolates in southern Ireland over a four-year period (2002-2006): variation in detection rates and evidence for continuing predominance of NoV GII.4 genotype. Archives of Virology, Vol. 159, Issue. 7, p. 1697.

Article contents

Molecular epidemiology of Norovirus strains circulating in Ireland from 2003 to 2004

Abstract

Save article to Kindle

Save article to Dropbox

Save article to Google Drive

Reply to: Submit a response

Your details

You have entered the maximum number of contributors

Conflicting interests