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The Mechanism of Phagocytosis from the Adsorption Point of View

Published online by Cambridge University Press:  15 May 2009

J. C. G. Ledingham
J. C. G. Ledingham
Affiliation:
(Lister Institute, London.)
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The two processes involved in the phagocytosis of bacilli (B. typhosus) by polymorphonuclear leucocytes in the presence of a sensitising fluid, viz. (1) the sensitisation of the micro-organism, and (2) the phagocytosis of the sensitised micro-organism, have been separately investigated. A single guinea-pig end-piece acted as the sensitising fluid throughout all the experiments.

The removal of opsonin by bacillary emulsions was found to run the course of an adsorption process as evidenced by the numerical relations found to subsist between the bound and free opsonin in equilibrium.

Also the actual phagocytosis of sensitised or partially sensitised micro-organisms suspended in a neutral fluid (physiological saline) was found, on analysis by similar numerical methods, to proceed as an adsorption process.

Type
Research Article
Information
Journal of Hygiene , Volume 12 , Issue 3 , October 1912 , pp. 320 - 360
Copyright
Copyright © Cambridge University Press 1912

References

REFERENCES

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