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Laboratory evaluation of difenacoum as a rodenticide*

Published online by Cambridge University Press:  15 May 2009

M. R. Hadler ,
R. Redfern  and
F. P. Rowe
M. R. Hadler
Affiliation:
Sorex (London) Ltd, Research Department, Halebank Factory, Lower Road, Widnes, Cheshire
R. Redfern
Affiliation:
Pest Infestation Control Laboratory, Ministry of Agriculture, Fisheries and Food, Hook Rise South, Tolworth, Surbiton, Surrey
F. P. Rowe
Affiliation:
Pest Infestation Control Laboratory, Ministry of Agriculture, Fisheries and Food, Hook Rise South, Tolworth, Surbiton, Surrey
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Summary

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The efficacy of difenacoum as a new anticoagulant rodenticide was evaluated by blood coagulation studies and laboratory feeding tests using warfarin-resistant and non-resistant common rats (Rattus norvegicus), ship rats (R. rattus) and house mice (Mus musculus). Prothrombin assays indicated that the compound had as marked an activity with warfarin-resistant common rats as coumatetralyl had with non-resistant animals. Feeding tests confirmed that 0.005% would be a near-optimal concentration for field use, although there was some evidence of unpalatability.

Results with ship rats and house mice were less favourable. Trials with enclosed colonies of warfarin-resistant mice confirmed the laboratory finding that although difenacoum was more effective than all other currently used anticoagulants, it was unlikely to give complete control.

It is concluded that difenacoum is a valuable new rodenticide, especially for controlling warfarin-resistant common rats.

Type
Research Article
Information
Journal of Hygiene , Volume 74 , Issue 3 , June 1975 , pp. 441 - 448
Copyright
Copyright © Cambridge University Press 1975

References

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