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Laboratory characteristics of an attenuated influenza type A (H3N2) virus (‘Alice’ strain)

Published online by Cambridge University Press:  15 May 2009

Michèle Lobmann ,
Andrée Delem ,
J. Peetermans  and
C. Huygelen
Michèle Lobmann
Affiliation:
Biologies Department, Recherche et Industrie Therapeutiques, R.I.T. rue de l'Institut 89, B-1330, Rixensart, Belgium
Andrée Delem
Affiliation:
Biologies Department, Recherche et Industrie Therapeutiques, R.I.T. rue de l'Institut 89, B-1330, Rixensart, Belgium
J. Peetermans
Affiliation:
Biologies Department, Recherche et Industrie Therapeutiques, R.I.T. rue de l'Institut 89, B-1330, Rixensart, Belgium
C. Huygelen
Affiliation:
Biologies Department, Recherche et Industrie Therapeutiques, R.I.T. rue de l'Institut 89, B-1330, Rixensart, Belgium
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Summary

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The Alice strain of live attenuated influenza virus was obtained by selection of a γ inhibitor-resistant strain from a virus recombinant between A/PR/8/34 (H0N1) and A/England/42/72 (H3N2). Its behaviour in vitro and in vivo was studied. Three marker systems were investigated: resistance to serum inhibitors, growth capacity at high temperature and low sensitivity to amantadine hydrochloride. In ferrets the strain was found to be attenuated and immunogenic. Passages in man, animals and eggs have not affected its resistance to γ inhibitors.

Type
Research Article
Information
Journal of Hygiene , Volume 77 , Issue 2 , October 1976 , pp. 181 - 188
Copyright
Copyright © Cambridge University Press 1976

References

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