Hostname: page-component-7479d7b7d-m9pkr Total loading time: 0 Render date: 2024-07-12T05:41:15.424Z Has data issue: false hasContentIssue false
  • English
  • Français

Isolation of Neisseria meningitidis strains with increase of penicillin minimal inhibitory concentrations

Published online by Cambridge University Press:  19 October 2009

J. A. Sáez-Nieto ,
D. Fontanals ,
J. Garcia De Jalon ,
V. Martinez De Artola ,
P. Peña ,
M. A. Morera ,
R. Verdaguer ,
I. Sanfeliu ,
C. Belio-Blasco  and
J. L. Perez-Saenz
...Show all authors
J. A. Sáez-Nieto
Affiliation:
Centro Nacional de Microbiología, Virologia e Immunologia Sanitarias, Majadahonda, Madrid, Spain
D. Fontanals
Affiliation:
Clinica Infantil Nen Jesus, Sabadell, Barcelona, Spain
J. Garcia De Jalon
Affiliation:
Hospital Virgen del Camino, Pamplona, Spain
V. Martinez De Artola
Affiliation:
Ciudad Sanitaria La Paz, Madrid, Spain
P. Peña
Affiliation:
Hospital de Sant Llátzer, Terrassa, Barcelona, Spain
M. A. Morera
Affiliation:
Hospital de Bellvitge, Hospitalet, Barcelona, Spain
R. Verdaguer
Affiliation:
Hospital de San Juan de Dios, Barcelona, Spain
I. Sanfeliu
Affiliation:
Hospital de San Millan, Logroño, Spain
C. Belio-Blasco
Affiliation:
Hospital San Jaime y Santa Magdalena, Mataró, Barcelona, Spain.
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

We report the isolation and characterization of ten strains showing an increase in the minimal inhibitory concentrations to penicillin (MICs > 0·1 μg/ml), and describe the epidemiological, clinical and microbiological features.

The susceptibility of 3432 meningococcal strains isolated from patients in the recent epidemic wave (1978–86) in Spain, to several antimicrobial agents used in the treatment and chemoprophylaxis of meningococcal infection has been tested. Most were resistant to sulphadiazine but sensitive to other antibiotics.

The possible existence of a new pattern of behaviour of meningococcal to penicillin is discussed.

Type
Research Article
Information
Epidemiology & Infection , Volume 99 , Issue 2 , October 1987 , pp. 463 - 469
Copyright
Copyright © Cambridge University Press 1987

References

REFERENCES

Campos, J., Garcia-Tornel, S. & Sanfeliu, I. (1984). Susceptibility studies of multiply resistant Haemophilus influenzae isolated form pediatric patients and contacts. Antimicrobial Agents and Chemotherapy 25, 706–709.Google Scholar
Casal, J. (1982). Antimicrobial susceptibility of Streptococcus pneumoniae: Serotype distribution of penicillin-resistant strains in Spain. Antimicrobial Agent and Chemotherapy 22, 222–225.Google Scholar
Contoyiannis, P. & Adamopoulos, D. A. (1974). Penicillin-resistant Neisseria meningitidis. Lancet i, 462.Google Scholar
Devine, L. F. & Hagerman, C. R. (1970). Spectra of susceptibility of Neisseria meningitidis to antimicrobial agents in vitro. Applied Microbiology 19, 329–334.Google Scholar
Dillon, J. R., Pauze, M. & Yeung, K. H. (1983). Spread of penicillinase-producing and transfer plasmids from gonococcus to Neisseria meningitidis. Lancet i, 779–781.CrossRefGoogle Scholar
Dominguez, P. & Minguella, I. (1985). Existencia de cepas de meningococo resistentes a penicilina. Medicina Clínica 85, 517–518.Google Scholar
Eickhoff, T. C. (1971). In vitro and In vivo studies of resistance to rifampin in meningococci. Journal of Infectious Diseases 123, 414–420.CrossRefGoogle ScholarPubMed
Eickhoff, T. C. & Finland, M. (1965). Changing susceptibility of meningococci to antimicrobial agents. New England Journal of Medicine 272, 395–398.CrossRefGoogle ScholarPubMed
Hieber, J. P. & Nelson, J. D. (1977). A pharmacologic evaluation of penicillin in children with purulent meningitis. New England Journal of Medicine 297, 410–413.Google Scholar
Jacobs, M. R., Koornhof, H. J., Robins-Browne, R. M., Stevenson, C. M., Vermaak, Z. A., Freiman, I., Miller, G. B., Witcomb, M. A., Isaacson, M., Ward, J. & Austrian, R. (1978). Emergence of multiply resistant pneumococci. New England Journal of Medicine 299, 735–740.Google Scholar
Liñares, J., Garau, J., Dominguez, C. & Perez, J. L. (1983). Antibiotic resistance and serotypes of Streptococcus pneumoniae from patients with community-acquired pneumococcal disease. Antimicrobial Agents and Chemotherapy 23, 545–547.CrossRefGoogle ScholarPubMed
Mancebo, J., Domingo, P., Net, A. & Nolla, J. (1985). Existencia de cepas de meningococo resistentes a penicilina. Medicina Clinica 84, 543–544.Google Scholar
Sáez-Nieto, J. A. (1985). Informe de la activitad del Laboratorio de Referencia de Meningococos (1978–1984). Instituto Nacional de Sanidad. Ministerio de Sanidad y Consumo, pp. 1–43. Madrid. Spain.Google Scholar
Sáez-Nieto, J. A., Fenoll, A., Vazquez, J. & Casal, J. (1982). Prevalence of maltose-negative Neisseria meningitidis variants during an epidemic period in Spain. Journal of Clinical Microbiology 15, 78–81.CrossRefGoogle ScholarPubMed
Sáez-Nieto, J. A., Garcia-Barreno, B., Lopez-Galindez, C. & Casal, J. (1981 a). Meningitis meningocócica en España (1978–1980). II. Serotipos y patrones electroforéticos en gel de poliacrilamida. Revista de Sanidad e Higiene Pública 55, 1295–1308.Google ScholarPubMed
Sáez-Nieto, J. A., Llager, A., Catala, F., Fenoll, A. & Casal, J. (1981 b). Meningitis meningocócica en España (1978–1980). I. Estudios epidemiológicos, serogrupos y sensibilidad a antimicrobianos. Revista de Sanidad e Higiene Pública 55, 831–869.Google ScholarPubMed
Saez-Nieto, J. A., Vazquez, J. & Casal, J. (1983). Meningitis meningocócica en España (1978–1981). III. Susceptibilidad do cepas de miningococo aislados de enfermos y portadores frente a los principales agentes usados en el tratamicnto y la quimioprofilaxis do la infeccion meningocócica. Revista de Sanidad e Higiene Pública 57, 587–602.Google Scholar
Scribner, R. K., Wedro, B. C., Weber, A. H. & Marks, M. I. (1982). Activities of eight betalactam antibiotics and seven antibiotic combinations against Neisseria meningitidis. Antimicrobial Agents and Chemotherapy 21, 678–680.Google Scholar
Ward, J. (1981). Antibiotic-resistant Streplococcus pneumoniae: clinical and epidemiological aspects. Review of Infectious Diseases 3, 254–266.CrossRefGoogle Scholar