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Inoculation of hamsters with a temperature sensitive (ts) mutant of parainfluenza 3 virus*

Published online by Cambridge University Press:  15 May 2009

N. Zygraich ,
Michèle Lobmann  and
C. Huygelen
N. Zygraich
Affiliation:
Biologies Department, Recherche et Industrie Therapeutiques (R.I.T.), Rixensart, Belgium
Michèle Lobmann
Affiliation:
Biologies Department, Recherche et Industrie Therapeutiques (R.I.T.), Rixensart, Belgium
C. Huygelen
Affiliation:
Biologies Department, Recherche et Industrie Therapeutiques (R.I.T.), Rixensart, Belgium
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Summary

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The multiplication pattern of a temperature-sensitive (ts) mutant of bovine parainfluenza 3 virus was studied in hamsters and compared with that of a virulent virus strain. The ts mutant was recovered regularly from the nasal mucosa and not from the lungs, whereas the virulent virus multiplied in the lungs as well as in the nasal mucosa.

The serological response induced by the mutant was comparable to that obtained after inoculation of the virulent virus.

This ts mutant may be a potential candidate for a live intranasal vaccine against bovine parainfluenza 3 infection.

Type
Research Article
Information
Journal of Hygiene , Volume 70 , Issue 2 , June 1972 , pp. 229 - 234
Copyright
Copyright © Cambridge University Press 1972

References

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