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Incomplete Antibodies in Experimental Brucella Infection

Published online by Cambridge University Press:  15 May 2009

J. C. Cruickshank
J. C. Cruickshank
Affiliation:
London School of Hygiene and Tropical Medicine
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Incomplete antibodies demonstrable by the Coombs antiglobulin technique were found in almost all guinea-pigs inoculated subcutaneously with Brucella abortus. They were detected between the 20th and 30th day after infection and reached a peak between the 50th and 70th day, at which time their titre was 4—8 times that of the ordinary agglutinins.

Paper electrophoresis of sera from infected guinea-pigs showed a great increase in y-globulin as infection developed. Smaller increases in α1- and β-globulin were observed.

Type
Research Article
Information
Journal of Hygiene , Volume 54 , Issue 4 , December 1956 , pp. 562 - 568
Copyright
Copyright © Cambridge University Press 1956

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