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Impact on the medical decision-making process of multiplex PCR assay for respiratory pathogens

  • A. GUILLON (a1), S. AYMERIC (a2), C. GAUDY-GRAFFIN (a3), J. SONKE (a2), M. P. DEBLONDE (a2), J. CAPSEC (a2), P. DIOT (a4), D. GAROT (a5), A. GOUDEAU (a3) and L. GRAMMATICO-GUILLON (a6)...

Summary

The objective of this study was to determine how clinicians make use of the modern multiplex PCR assays (MPAs) to manage patients hospitalized for community-acquired pneumonia (CAP). We studied the use of MPAs in 1648 patients hospitalized for CAP over a 3-year period at the moment of the setup of the new PCR assay. We observed that the use of MPAs for the identification of multiple respiratory pathogens marks a radical change in the investigation of CAP etiology. Surprisingly, the contribution of MPAs to the medical decision-making process varies drastically according to the units of care.

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Copyright

Corresponding author

*Author for correspondence: Dr L. Grammatico-Guillon, MD PhD, Teaching Hospital of Tours, Regional Unit of Epidemiology, 2 BD Tonnellé 37044 tours cedex 9, France. (Email: Leslie.guillon@univ-tours.fr)

References

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1. Grammatico-Guillon, L, et al. Study of hospitalizations for pneumococcal pneumoniae in centre region, 2004–2008. Revue d'Epidemiol Sante Publique 2012; 60: 18.
2. Wunderink, RG, Waterer, GW. Clinical practice. Community-acquired pneumonia. New England Journal Medicine 2014; 370: 543551.
3. Vincent, J-L, et al. Rapid diagnosis of infection in the critically Ill, a multicenter study of molecular detection in bloodstream infections, pneumonia, and sterile site infections. Critical Care Medicine 2015; 43: 22832291.
4. Gadsby, NJ, et al. Comprehensive molecular testing for respiratory pathogens in community-acquired pneumonia. Clinical Infectious Diseases 2016; 62: 817823.
5. Subramony, A, et al. Impact of multiplex polymerase chain reaction testing for respiratory pathogens on healthcare resource utilization for pediatric inpatients. Journal of Pediatrics 2016; 173: 196201.
6. Contentin, L, et al. Acute respiratory distress syndrome secondary to human metapneumovirus infection in a young healthy adult. Intensive Care Medicine 2013; 39: 533534.
7. Schnepf, N, et al. High burden of non-influenza viruses in influenza-like illness in the early weeks of H1N1v epidemic in France. PLoS ONE 2011; 6: e23514.
8. Burk, M, et al. Viral infection in community-acquired pneumonia: a systematic review and meta-analysis. European Respiratory Revue 2016; 25: 178188.

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Impact on the medical decision-making process of multiplex PCR assay for respiratory pathogens

  • A. GUILLON (a1), S. AYMERIC (a2), C. GAUDY-GRAFFIN (a3), J. SONKE (a2), M. P. DEBLONDE (a2), J. CAPSEC (a2), P. DIOT (a4), D. GAROT (a5), A. GOUDEAU (a3) and L. GRAMMATICO-GUILLON (a6)...

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