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Immunogenicity of specific Bordetella pertussis surface antigens in diphtheria-tetanus-pertussis (DTP) vaccines

Published online by Cambridge University Press:  19 October 2009

Alan C. Blaskett  and
John C. Cox
Alan C. Blaskett
Affiliation:
Bacteriology R & D, Commonwealth Serum Laboratories, 45 Poplar Road, Parkville, 3052, Australia
John C. Cox
Affiliation:
Bacteriology R & D, Commonwealth Serum Laboratories, 45 Poplar Road, Parkville, 3052, Australia
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Summary

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The predominant causative organism of whooping cough in Australia is of a serotype which has normally been associated overseas with unvaccinated communities. Australian DTP vaccines pass the statutory mouse test for Bordetella pertussis potency but this test is now believed to be relatively insensitive to certain factors, especially the major type-specific agglutinogens, which are presumably also important in the human host-parasite relationship. Because endemic B. bronchiseptica infections make some laboratory animals unsatisfactory for testing B. pertussis agglutinin responses, we have developed a test in which young farm sheep were immunized with vaccines. Type-specific agglutinins in their sera were assayed after absorption of non-specific agglutinins by suspensions of selected bordetella strains. Three well-reputed European DTP vaccines and two recent batches of Australian DTP vaccine were tested and compared thus. All evoked significant agglutinin responses to the main agglutinogens.

Type
Research Article
Information
Epidemiology & Infection , Volume 100 , Issue 3 , June 1988 , pp. 335 - 344
Copyright
Copyright © Cambridge University Press 1988

References

Agarwal, K. C. & Preston, N. W. (1976). Pertussis agglutinins in vaccinated mice: difficulty in estimating the type-specific response. Indian Journal of Medical Research 64, 393–398.Google ScholarPubMed
Ashworth, L. A. E., Fitzgeorge, R. B., Irons, L. I., Morgan, C. P. & Robinson, A. (1982). Rabbit nasopharyngeal colonization by Bordetella pertussis: the effects of immunization on clearance and on serum and nasal antibody levels. Journal of Hygiene 88, 475–480.CrossRefGoogle ScholarPubMed
Blaskett, A. C. (1979). Discussion. Proceedings of the 3rd International Symposium on Pertussis (ed. C. R. Manclark and J. C. Hill), p. 59. Bethesda, DHEW Publication No. (NIH) 79–1830.Google Scholar
Blaskett, A. C., Gulasekharam, J. & Fulton, L. C. (1971). The occurrence of Bordetella pertussis serotypes in Australia, 1950–1970. Medical Journal of Australia i, 781–784.CrossRefGoogle Scholar
Blaskett, A. C., Marley, P. B. & Roberton, D. M. (1986). Serum antibody levels following immunisation with diphtheria-tetanus-pertussis (DTP) vaccines. Australian Microbiologist 7, 143.Google Scholar
British Pharmacopoeia (1980). Vol. II. Biological assay of pertussis vaccine; Appendix xiv, B.10: A131–132.Google Scholar
Bronne-Shanbury, C. J. (1976). The importance of agglutinin production in mice in the determination of the definitive serotype of Bordetella pertussis. Journal of Hygiene 76, 257–264.CrossRefGoogle ScholarPubMed
Cohen, S. M. & Wheeler, M. W. (1946). Pertussis vaccine prepared with phase I cultures grown in fluid medium. American Journal of Public Health 36, 371–376.CrossRefGoogle ScholarPubMed
Communicable Diseases Committee (1978). National Health and Medical Research Council, Australia. Report of 86th session, Canberra, 20–21 Oct.Google Scholar
Cruickshank, R., Duguid, J. P., Marmion, B. P. & Swain, R. H. A. (1975). Medical Microbiology, 12th edn, vol. 2, p. 55. Edinburgh, London and New York: Churchill Livingstone.Google Scholar
de Bock, C. A. & Worst Van Dam, A. M. (1960). Fixation of the agglutinogen from Haemophilus pertussis on the bacterial surface. Antonie van Lieuwenhoek Journal of Microbiology and Serology 26, 126–128.CrossRefGoogle ScholarPubMed
Eldering, G., Hornbeck, C. & Baker, J. (1957). Serological study of Bordetella pertussis and related species. Journal of Bacteriology 74, 133–136.CrossRefGoogle ScholarPubMed
Gapes, M. (1984). Pertussis in Sydney 1974–1983. Australian Microbiologist 5, 130.Google Scholar
Goodnow, R. A. (1980). Biology of Bordetella bronchiseptica. Microbiological Reviews 44, 722–738.CrossRefGoogle ScholarPubMed
Holt, L. B. (1968). Pitfalls in the preparation of monotypic agglutinating antisera for Bordetella pertussis. Journal of Medical Microbiology 1, 170–180.CrossRefGoogle ScholarPubMed
Kauffmann, F. (1954). Enterobacteriaceae, 2nd edn, pp. 59–60. Copenhagen: Ejnar Munksgaard.Google Scholar
Kuronen, J. & Huovila, R. (1979). Seroresponse to pertussis vaccine. In Proceedings of the 3rd International Symposium on Pertussis (ed. Manclark, C. R. and Hill, J. C.), pp. 34–40. Bethesda, DHEW Publication No. (NIH) 79–1830.Google Scholar
Maitland, H. B., & Guerault, A. (1958). Some surface components of Haemophilus pertussis: immunizing antigen, histamine-sensitising factor and agglutinogen. Journal of Pathology and Bacteriology 76, 257–274.CrossRefGoogle ScholarPubMed
Manclark, C. R. & Meade, B. D. (1980). Serological response to Bordetella pertussis. In Manual of Clinical Immunology, 2nd edn (ed. Rose, N. R. and Friedman, H.), pp. 496–499. Washington, D.C.: American Society for Microbiology.Google Scholar
Preston, N. W. (1966). Potency tests for pertussis vaccines: doubtful value of intracerebral challenge test in mice. Journal of Pathology and Bacteriology 91, 173–179.CrossRefGoogle ScholarPubMed
Preston, N. W. (1970 a). Technical problems in the laboratory diagnosis and prevention of whooping cough. Laboratory Practice 19, 482–486.Google ScholarPubMed
Preston, N. W. (1970 b). Pertussis agglutinins in the child. Proceedings of International Symposium on Pertussis, Bilthoven, 1969. In Symposia Series in Immunobiological Standardization, vol. 13 (ed. van Hemert, P. A., van Ramshorst, J. D. and Regamey, R. H.), pp. 121–125. Basel, Munchen & New York: S. Karger.Google Scholar
Preston, N. W. (1976). Prevalent serotypes of Bordetella pertussis in non-vaccinated communities. Journal of Hygiene 77, 85–91.CrossRefGoogle ScholarPubMed
Preston, N. W. & Carter, E. J. (1986). Surveillance of pertussis infection in Britain, 1977–1985. Public Health Laboratory Service Communicable Diseases Report 86 (27), 3–4.Google Scholar
Preston, N. W. & Stanbridge, T. N. (1976). Mouse or man? Which are pertussis vaccines to protect? Journal of Hygiene 76, 249–256.CrossRefGoogle ScholarPubMed
Preston, N. W. & TePunga, W. A. (1959). The relation between agglutinin production by pertussis vaccines and their immunising potency in mice. Journal of Pathology and Bacteriology 78, 209–216.CrossRefGoogle ScholarPubMed
Robinson, A. & Irons, L. I. (1983). Synergistic effect of Bordetella pertussis lymphocytosis promoting factor on protective activities of isolated Bordetella antigens in mice. Infection and Immunity 40, 523–528.CrossRefGoogle ScholarPubMed
Robinson, A., Irons, L. I. & Ashworth, L. A. E. (1985). Pertussis vaccine: present status and future prospects. Vaccine 3, 10–22.CrossRefGoogle ScholarPubMed
Taylor, L. (1984). Bordetella pertussis epidemic in Auckland. Australian Microbiologist 5, 130.Google Scholar
Whooping Cough Immunization Committee of Medical Research Council et al. (1956). Vaccinating against whooping cough: relation between protection in children and results of laboratory tests. British Medical Journal ii, 454–457.Google Scholar