Hostname: page-component-77c89778f8-gq7q9 Total loading time: 0 Render date: 2024-07-18T07:38:56.280Z Has data issue: false hasContentIssue false
  • English
  • Français

Immunogenic variation among the so-called LC strains of Mycoplasma mycoides subspecies mycoides

Published online by Cambridge University Press:  15 May 2009

G. R. Smith  and
Janet C. Oliphant
G. R. Smith
Affiliation:
Nuffield Laboratories of Comparative Medicine, Institute of Zoology, The Zoological Society of London, Regent's Park, London NW1 4RY
Janet C. Oliphant
Affiliation:
Nuffield Laboratories of Comparative Medicine, Institute of Zoology, The Zoological Society of London, Regent's Park, London NW1 4RY
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Much evidence of immunogenic heterogeneity among the LC strains of Mycoplasma mycoides ssp. mycoides emerged from cross-immunization and hyperimmunization experiments in mice in which three LC strains (Vom/Plum Island, 74/2488, and Mankefår 2833) were used for challenge purposes. All heterologous LC-strain vaccines cross-immunized against the three challenge strains, but protection was usually only ‘partial’, i.e. significantly less than that given by homologous vaccine. Cross-hyperimmunization with all heterologous LC but not SC strains produced protection against challenge with Vom/Plum Island that was virtually ‘complete’, i.e. similar to that produced by homologous vaccine. Challenge with 74/2488 gave generally similar results; but against Mankefår 2833 six heterologous LC vaccines gave complete protection and six did not.

Vaccines prepared from the Smith (1423) strain of M. mycoides ssp. capri gave some protection against Vom/Plum Island but none against 74/2488 or Mankefrr 2833. The cross-immunizing ability of three further M. mycoides ssp. capri strains appeared to resemble that of Smith (1423).

In a cross-hyperimmunization experiment, vaccines prepared from SC strains of M. mycoides ssp. mycoides varied greatly in their ability to protect against challenge with strains 74/2488 and Mankefår 2833.

Type
Research Article
Information
Journal of Hygiene , Volume 90 , Issue 3 , June 1983 , pp. 441 - 449
Copyright
Copyright © Cambridge University Press 1983

References

REFERENCES

Cottew, G. S. & Yeats, F. R. (1978). Subdivision of Mycoplasma mycoides subsp. mycoides from cattle and goats into two types. Australian Veterinary Journal 54, 293–296.CrossRefGoogle ScholarPubMed
Hooker, J. M., Smith, G. R. & Milligan, R. A. (1979). Differentiation of Mycoplasma mycoides subsp. mycoides from certain closely related mycoplasmas by mycoplasmaemia and cross-protection tests in mice. Journal of Hygiene 82, 407–418.Google Scholar
Report (1979). Proposal of minimal standards for descriptions of new species of the class Mollicutes. International Journal of Systematic Bacteriology 29, 172–180.Google Scholar
Smith, G. R. (1967). Mycoplasma mycoides var. mycoides: production of bacteriaemia and demonstration of passive immunity in mice. Journal of Comparative Pathology 77, 203–209.Google Scholar
Smith, G. R. (1969 a). Effect of route of vaccination on the immune response of mice to a single dose of heat-killed Mycoplasma mycoides var. mycoides. Journal of Comparative Pathology 79, 255–260.CrossRefGoogle ScholarPubMed
Smith, G. R. (1969 b). A study of Mycoplasma mycoides var. mycoides and Mycoplasma mycoides var. capri by cross-protection tests in mice. Journal of Comparative Pathology 79, 261–265.CrossRefGoogle ScholarPubMed
Smith, G. R. (1971). The use of mice in research on contagious bovine pleuropneumonia. Tropical Animal Health and Production 3, 169–172.CrossRefGoogle ScholarPubMed
Smith, G. R., Hooker, J. M. & Milligan, R. A. (1980). Further studies on caprine and ovine mycoplasmas related to Mycoplasma mycoides subsp. mycoides. Journal of Hygiene 85, 247–256.CrossRefGoogle ScholarPubMed
Smith, G. R. & Oliphant, J. C. (1981 a). The ability of Mycoplasma mycoides subspecies mycoides and closely related strains from goats and sheep to immunize mice against subspecies capri. Journal of Hygiene 87, 321–329.Google Scholar
Smith, G. R. & Oliphant, J. C. (1981 b). Observations on the antigenic differences between the so-called SC and LC strains of Mycoplasma mycoides subsp. mycoides. Journal of Hygiene 87, 437–442.CrossRefGoogle ScholarPubMed
Smith, G. R. & Oliphant, J. C. (1982). Some in-vitro characters of the subspecies of Mycoplasma mycoides. Journal of Hygiene 89, 521–527.Google Scholar
Turner, A. W., Campbell, A. D. & Dick, A. T. (1935). Recent work on pleuropneumonia contagiosa boum in North Queensland. Australian Veterinary Journal 11, 63–71.CrossRefGoogle Scholar
Valdivieso-Garcia, A. & Rosendal, S. (1982). Variation in colony size of Mycoplasma mycoides subspecies mycoides isolated from goats. Veterinary Record 110, 470–471.CrossRefGoogle ScholarPubMed