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The immunization of mice and calves with gal E mutants of Salmonella typhimurium

  • C. Wray (a1), W. J. Sojka (a1), J. A. Morris (a1) and W. J. Brinley Morgan (a1)

Summary

A galactose epimeraseless (gal E) mutant of Salmonella typhimurium was investigated in mice and calves for its suitability as a live vaccine. In mice, a very highly significant difference in the mortality rates was observed when vaccinated and non-vaccinated animals were challenged with virulent strains of S. typhimurium and S. dublin.

In calves, doses of 106 and above of gal E mutant injected subcutaneously provided highly significant protection both in terms of mortality and prevalence of symptoms when calves were challenged orally with S. typhimurium. However, there appeared to be a relation between the vaccine and the presence of renal lesions and before gal E mutants can be recommended, further work is necessary to determine the pathogenesis of these lesions.

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References

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The immunization of mice and calves with gal E mutants of Salmonella typhimurium

  • C. Wray (a1), W. J. Sojka (a1), J. A. Morris (a1) and W. J. Brinley Morgan (a1)

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