Hostname: page-component-7479d7b7d-wxhwt Total loading time: 0 Render date: 2024-07-11T00:00:04.491Z Has data issue: false hasContentIssue false
  • English
  • Français

Immunity to salmonella infection in mice*

Published online by Cambridge University Press:  15 May 2009

D. R. E. MacLeod
D. R. E. MacLeod
Affiliation:
Connaught Medical Research Laboratories, University of Toronto, Toronto, Canada
Rights & Permissions [Opens in a new window]

Extract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Experiments on immunity produced by vaccine were carried out in mice with two strains of salmonella.

Against intraperitoneal challenge protection was such that 40–80 % of vaccinated mice survived a dose that killed almost all controls. This level of immunity appeared to be maintained with little change for at least 5–7 months. An explanation for this stability is suggested.

Against infection by the natural route, either by direct feeding or by exposure to infected animals, protection from vaccine was of a comparatively low order.

Resistance to infection by an artificial route was, therefore, not a measure of resistance to infection by the natural route.

Type
Research Article
Information
Journal of Hygiene , Volume 52 , Issue 1 , March 1954 , pp. 9 - 17
Copyright
Copyright © Cambridge University Press 1954

References

REFERENCES

Carnochan, F. G. & Cumming, C. N. W. (1952). Immunisation against salmonella infection in a breeding colony. J. infect. Dis. 90, 242.CrossRefGoogle Scholar
Greenwood, M., Topley, W. W. C. & Wilson, J. (1931). Contributions to the experimental study of epidemiology. J. Hyg., Camb., 31, 257.CrossRefGoogle Scholar
Ibrahim, H. M., & Schütze, H. (1928). A comparison of the prophylactic values of the H, O and R antigens of Salmonella aertrycke, together with some observations on the toxicity of its smooth and rough variants. Brit. J. exp. Path. 9, 353.Google Scholar
Prichett, Ida W. (1924). Homologous and heterologous protection in mice vaccinated with the two types of mouse typhoid bacillus. J. exp. Med. 39, 265.CrossRefGoogle Scholar
Reid, D. B. W. & MacLeod, D. R. E. (1954). The relation between dose and mortality for Salmonella dublin. J. Hyg., Camb., 52, 18.CrossRefGoogle ScholarPubMed
Topley, W. W. C., Wilson, G. S. & Miles, A. A. (1946). Principles of Bacteriology and Immunity, 3rd ed. London: E. Arnold and Co.CrossRefGoogle Scholar
Webster, L. T. (1922). Experiments on normal and immune mice with bacillus of mouse typhoid. J. exp. Med. 36, 71.CrossRefGoogle ScholarPubMed