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Identification of pregnancies at risk from cytomegalovirus infection

Published online by Cambridge University Press:  15 May 2009

L. M. de Silva ,
G. L. Kampfner ,
C. M. Lister  and
J. O.'H. Tobin
L. M. de Silva
Affiliation:
Public Health Laboratory, Withington Hospital, Manchester, M20 8LR
G. L. Kampfner
Affiliation:
Public Health Laboratory, Withington Hospital, Manchester, M20 8LR
C. M. Lister
Affiliation:
Public Health Laboratory, Withington Hospital, Manchester, M20 8LR
J. O.'H. Tobin
Affiliation:
Public Health Laboratory, Withington Hospital, Manchester, M20 8LR
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Summary

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The fluorescent antibody technique was used for the identification of specific cytomegalovirus IgM in the sera of twenty-four of 1065 unmarried pregnant women. Seventeen of them were followed to term and five infected infants were identified. Two other infants had CMV IgM in neonatal serum samples but virus excretion was not demonstrated. The congenital infection rate in this study was 5·3 per 1000 births by virus excretion and 7·9 per 1000 if cases with specific IgM are included; from previous studies a rate of 8·8 per 1000 was expected. The reasons for the lack of relationship between specific IgM in the mothers' serum and infected babies is discussed.

Type
Research Article
Information
Journal of Hygiene , Volume 79 , Issue 3 , December 1977 , pp. 347 - 354
Copyright
Copyright © Cambridge University Press 1977

References

REFERENCES

Collaborative Study (1970). Cytomegalovirus infection in the North-West of England. Archives of Disease in Childhood 45, 513.CrossRefGoogle Scholar
De Silva, L. M., Khan, M. S., Kampfner, G. & Tobin, J. O'H. (1973). The post-mortem diagnosis of influenzal infection by fluorescent IgG, IgA and IgM antibody studies on necropsy blood. Journal of Hygiene 71, 107.CrossRefGoogle ScholarPubMed
Elek, S. D. & Stern, H. (1974a). Development of a vaccine against mental retardation caused by CMV infection in utero. Lancet, i, 1.CrossRefGoogle Scholar
Elek, S. D. & Stern, H. (1974b). Vaccination against cytomegalovirus? Lancet i, 171.CrossRefGoogle Scholar
Embrey, M. P. (1975). The Prostaglandins in Human Reproduction. Edinburgh: Churchill Livingstone.Google Scholar
Hanshaw, J. B., Niederman, J. C. & Chessin, L. N. (1972). Cytomegalovirus macroglobulins in cell-associated herpesvirus infections. Journal of Infectious Diseases 125, 304.CrossRefGoogle ScholarPubMed
Hanshaw, J. B., Sternfield, H. J. & White, C. J. (1968). Fluorescent-antibody test for cytomegalovirus macroglobulin. New England Journal of Medicine 279, 566.CrossRefGoogle ScholarPubMed
Nagington, J. (1971). Cytomegalovirus antibody in renal transplant patients. Journal of Hygiene 69, 645.Google ScholarPubMed
Schmitz, H. & Haas, R. (1972). Determination of different cytomegalovirus immunoglobulins (IgG, IgA, IgM) by immunofluorescence. Archiv für die gesamte Virusforschung 37, 131.CrossRefGoogle ScholarPubMed
Schmitz, H., Kampa, D., Doerr, H. W., Luthardt, T., Hillemanns, H. G. & Würtele, A. (1977). IgM antibodies to cytomegalovirus during pregnancy. Archives of Virology 53, 177.CrossRefGoogle Scholar
Shirodaria, R., Frazer, K. B. & Stanford, F. (1973). Secondary fluorescent staining of virus antigens by rheumatoid factor and conjugated anti-IgM. Annals of the Rheumatic Diseases 32, 53.CrossRefGoogle ScholarPubMed
Stern, H. & Tucker, S. M. (1973). Prospective study of cytomegalovirus infection in pregnancy. British Medical Journal ii, 268.CrossRefGoogle Scholar
Tobin, J.O'H. (1973). The virus laboratory in the diagnosis and prevention of congenital infections. Ciba Foundation Symposium No. 10. Intrauterine infections, p. 53. Amsterdam: Associated Scientific Publishers.Google Scholar