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Homologous and heterologous antibody responses to subunit influenza virus vaccine

Published online by Cambridge University Press:  15 May 2009

Brian J. Feery ,
M. G. Evered  and
Kathleen Hayes
Brian J. Feery
Affiliation:
WHO National Influenza Centre, Commonwealth Serum Laboratories, Parkville 3052, Australia
M. G. Evered
Affiliation:
WHO National Influenza Centre, Commonwealth Serum Laboratories, Parkville 3052, Australia
Kathleen Hayes
Affiliation:
Department of Pediatrics, Monash University, Melbourne 3000, Australia
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Summary

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In a group of 32 adult volunteers given subunit influenza virus vaccine containing 250 international units (i.u.) of A/Victoria/3/75, 250 i.u. of A/Scotland/ 840/74 and 300 i.u. of B/Hong Kong/8/73, there were substantial increases in the geometric mean homologous haemagglutination-inhibiting (HI) antibody titres. There was also substantial boosting of the antibodies to the earlier variants of the Hong Kong (H3N2) series and to a later variant of the Asian (H2N2) series. There was no boosting of antibodies to the A/FM/1/47 strain, a representative member of the H1N1 series, but two individuals showed substantial rises to A/PR/8/34 (H0N1).

There were increases in the HI titre of antibodies cross reactive with two recent isolations, A/Texas/1/77, and A/Victoria/35/77, but the majority of vaccinees failed to reach antibody titres likely to be protective against such strains.

Type
Research Article
Information
Journal of Hygiene , Volume 81 , Issue 3 , December 1978 , pp. 331 - 336
Copyright
Copyright © Cambridge University Press 1978

References

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