High circulation of hepatitis B virus (HBV) precore mutants in Tunisia, North Africa

H. TRIKI; S. BEN SLIMANE; N. BEN MAMI; T. SAKKA; A. BEN AMMAR; K. DELLAGI

doi:10.1017/S0950268899003921

Abstract

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Hepatitis B Virus (HBV) e antigen (HBeAg), HBV DNA and precore mutations affecting HBeAg expression during active replication were studied in 72 Tunisian hepatitis B surface antigen (HBsAg) positive individuals: 30 asymptomatic carriers of the virus, 37 with chronic hepatitis and 5 with acute hepatitis. HBV DNA was detected in 44 patients, but only 20% of them expressed HBeAg. Precore mutant strains, with mutations at position 1896 or at positions 1896 and 1899, were detected by PCR-hybridization in 86 and 36% of patients, respectively. Wild-type strains were detected in 54% of patients. Precore mutants were found in chronically and in acutely infected individuals, in patients with severe and asymptomatic infections, in HBeAg positive as well as HBeAg negative individuals. These results show the high frequency of HBV precore mutants in Tunisia.

Crossref Citations

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Kreutz, C. 2002. Molecular, immunological and clinical properties of mutated hepatitis B viruses. Journal of Cellular and Molecular Medicine, Vol. 6, Issue. 1, p. 113.

Gandhe, S. S. Chadha, M. S. Walimbe, A. M. and Arankalle, V. A. 2003. Hepatitis B virus: prevalence of precore/core promoter mutants in different clinical categories of Indian patients. Journal of Viral Hepatitis, Vol. 10, Issue. 5, p. 367.

Bahri, O. Cheikh, I. Hajji, N. Djebbi, A. Maamouri, N. Sadraoui, A. Mami, N. Ben and Triki, H. 2006. Hepatitis B genotypes, precore and core promoter mutants circulating in Tunisia. Journal of Medical Virology, Vol. 78, Issue. 3, p. 353.

Hatzakis, Angelos Magiorkinis, Emmanouil and Haida, Catherine 2006. HBV virological assessment. Journal of Hepatology, Vol. 44, Issue. , p. S71.

Ayed, Khaled Gorgi, Yousr Ayed-Jendoubi, Saloua Aouadi, Houda Sfar, Imen Najjar, Tawfik and Ben Abdallah, Taieb 2007. Hepatitis B virus genotypes and precore/core-promoter mutations in Tunisian patients with chronic hepatitis B virus infection. Journal of Infection, Vol. 54, Issue. 3, p. 291.

Meldal, Birgit H. M. Moula, Najet Mojaat Barnes, If H. A. Boukef, Kamel and Allain, Jean-Pierre 2009. A novel hepatitis B virus subgenotype, D7, in Tunisian blood donors. Journal of General Virology , Vol. 90, Issue. 7, p. 1622.

Djebbi, A. Rebai, W.K. Bahri, O. Hogga, N. Sadraoui, A. and Triki, H. 2009. Marqueurs sérologiques, ARN viral et génotype du virus de l’hépatite delta chez des patients tunisiens antigène HBs positifs. Pathologie Biologie, Vol. 57, Issue. 7-8, p. 518.

Hannachi, N. Bahri, O. Mhalla, S. Marzouk, M. Sadraoui, A. Belguith, A. Triki, H. and Boukadida, J. 2009. Hépatite virale B chez les femmes enceintes tunisiennes : facteurs de risque et intérêt de l’étude de la réplication virale en cas d’antigène HBe négatif. Pathologie Biologie, Vol. 57, Issue. 3, p. e43.

Ben-Alaya-Bouafif, Nissaf Bahri, Olfa Chlif, Sadok Bettaieb, Jihène Toumi, Amine Bel Haj, Hamida Nabil Zâatour, Amor Gharbi, Adel Dellagi, Koussay Triki, Hinda and Ben Salah, Afif 2010. Heterogeneity of hepatitis B transmission in Tunisia: Risk factors for infection and chronic carriage before the introduction of a universal vaccine program. Vaccine, Vol. 28, Issue. 19, p. 3301.

Ouneissa, Rim Bahri, Olfa Alaya‐Bouafif, Nissaf Ben Chouaieb, Sofiene Yahia, Ahlem Ben Sadraoui, Amel Hammami, Walid Filali, Noureddine Azzouz, Mohamed Msaddak Mami, Nabyl Ben and Triki, Henda 2012. Frequency and clinical significance of core promoter and precore region mutations in Tunisian patients infected chronically with hepatitis B. Journal of Medical Virology, Vol. 84, Issue. 11, p. 1719.

Ayari, Rym Lakhoua-Gorgi, Yousr Bouslama, Lamjed Safar, Imen Kchouk, Fatma Houissa Aouadi, Houda Jendoubi-Ayed, Saloua Najjar, Taoufik Ayed, Kaled and Abdallah, Taieb Ben 2012. Investigation of DNA Sequence in the Basal Core Promoter, Precore, and Core Regions of Hepatitis B Virus from Tunisia Shows a Shift in Genotype Prevalence. Hepatitis Monthly, Vol. 12, Issue. 11,

Ezzikouri, Sayeh Pineau, Pascal and Benjelloun, Soumaya 2013. Hepatitis B virus in the Maghreb Region: from epidemiology to prospective research. Liver International, Vol. 33, Issue. 6, p. 811.

Suppiah, Jeyanthi Mohd Zain, Rozainanee Bahari, Norazlah Haji Nawi, Salbiah and Saat, Zainah 2015. G1896A Precore Mutation and Association With HBeAg Status, Genotype and Clinical Status in Patients With Chronic Hepatitis B. Hepatitis Monthly, Vol. 15, Issue. 10,

Yacoubi, Lamia Brichler, Ségolène Mansour, Wael Le Gal, Frédéric Hammami, Walid Sadraoui, Amel Ben Mami, Nabil Msaddek, Azouz Cheikh, Imed Triki, Henda and GORDIEN, Emmanuel 2015. Molecular epidemiology of hepatitis B and Delta virus strains that spread in the Mediterranean North East Coast of Tunisia. Journal of Clinical Virology, Vol. 72, Issue. , p. 126.

Zhand, Sareh Karami, Chiman Hosseinzadeh Adli, Ahmad Tabarraei, Alijan Khodabakhshi, Behnaz and Moradi, Abdolvahab 2015. Correlation Between Hepatitis B G1896A Precore Mutations and HBeAg in Chronic HBV Patients. Jundishapur Journal of Microbiology, Vol. 8, Issue. 2,

Mhalla, Salma Kadri, Yosr Alibi, Sana Letaief, Amel Boukadida, Jalel and Hannachi, Naila 2016. Hepatitis D Virus Infection Among Hepatitis B Surface Antigen Carriers and in “Isolated anti-HBc” Antibodies Profile in Central Tunisia. Hepatitis Monthly, Vol. 16, Issue. 1,

Ben Hadj, Meriem Bouguerra, Hind Saffar, Farah Chelly, Souhir Hechaichi, Aicha Talmoudi, Khouloud Bahrini, Asma Chouki, Takoua Hazgui, Olfa Hannachi, Naila Letaief, Hajer Bellali, Hedia Bahri, Olfa and Ben-Alaya-Bouafif, Nissaf 2018. Observational study of vaccine effectiveness 20 years after the introduction of universal hepatitis B vaccination in Tunisia. Vaccine, Vol. 36, Issue. 39, p. 5858.

Daw, Mohamed A. Daw, Amina M. Sifennasr, Nadia E. M. Draha, Aisha M. Daw, Ahmed M. Daw, Ali M. Ahmed, Mohamed O. Mokhtar, Ebtisam S. El-Bouzedi, Abdallah and Daw, Ibrahem M. 2018. The Epidemiology of Hepatitis D Virus in North Africa: A Systematic Review and Meta-Analysis. The Scientific World Journal, Vol. 2018, Issue. , p. 1.

Belaiba, Zeineb Ayouni, Kaouther Gdoura, Mariem Kammoun Rebai, Wafa Touzi, Henda Sadraoui, Amel Hammemi, Walid Yacoubi, Lamia Abdelati, Salwa Hamzaoui, Lamine Msaddak Azzouz, Mohamed Chouikha, Anissa and Triki, Henda 2022. Whole genome analysis of hepatitis B virus before and during long-term therapy in chronic infected patients: Molecular characterization, impact on treatment and liver disease progression. Frontiers in Microbiology, Vol. 13, Issue. ,

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High circulation of hepatitis B virus (HBV) precore mutants in Tunisia, North Africa

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