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Helicobacter pylori seropositivity is associated with antinuclear antibodies in US adults, NHANES 1999–2000

  • H. C. S. Meier (a1), F. W. Miller (a2), G. E. Dinse (a3), C. R. Weinberg (a4), C. C. Cho (a5) and C. G. Parks (a6)...

Abstract

Infectious diseases, such as Helicobacter pylori, which produce systemic inflammation may be one key factor in the onset of autoimmunity. The association between H. pylori and antinuclear antibodies (ANA), a marker of autoimmunity, has been understudied. Data from the 1999–2000 National Health and Nutrition Examination Survey were used to evaluate the cross-sectional association between H. pylori seroprevalence and ANA positivity in US adults aged ≥20 years. ANA was measured in a 1:80 dilution of sera by indirect immunofluorescence using HEp-2 cells (positive ⩾3). H. pylori immunoglobulin G enzyme-linked immunosorbent assays were used to categorise individuals as seropositive or seronegative. H. pylori seropositivity and ANA positivity were common in the adult US population, with estimated prevalences of 33.3% and 9.9%, respectively. Both were associated with increasing age. H. pylori seropositivity was associated with higher odds of ANA (prevalence odds ratio = 1.89, 95% confidence interval = 1.08–3.33), adjusted for age, sex, race/ethnicity, educational attainment and body mass index. H. pylori infection may be one key factor in the loss of self-tolerance, contributing to immune dysfunction.

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Copyright

To the extent this is a work of the US Government, it is not subject to copyright protection within the United States. Published by Cambridge University Press. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.

Corresponding author

Author for correspondence: H. C. S. Meier, E-mail: meierh2@uwm.edu

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Helicobacter pylori seropositivity is associated with antinuclear antibodies in US adults, NHANES 1999–2000

  • H. C. S. Meier (a1), F. W. Miller (a2), G. E. Dinse (a3), C. R. Weinberg (a4), C. C. Cho (a5) and C. G. Parks (a6)...

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