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Helicobacter pylori seropositive subjects do not show a pronounced systemic inflammatory response even in the presence of the interleukin-1 receptor antagonist gene polymorphism

Published online by Cambridge University Press:  09 December 2004

N. ZUMKELLER ,
W. KOENIG ,
M. M. HOFFMANN ,
H. KOLB ,
H. BRENNER  and
D. ROTHENBACHER
N. ZUMKELLER
Affiliation:
Department of Epidemiology, German Centre for Research on Ageing, Heidelberg, Germany
W. KOENIG
Affiliation:
Department of Internal Medicine II – Cardiology, University of Ulm Medical Centre, Ulm, Germany
M. M. HOFFMANN
Affiliation:
Department of Clinical Chemistry, University of Freiburg, Freiburg, Germany
H. KOLB
Affiliation:
German Diabetic Clinic, Research Institute at the University of Düsseldorf, Düsseldorf, Germany
H. BRENNER
Affiliation:
Department of Epidemiology, German Centre for Research on Ageing, Heidelberg, Germany
D. ROTHENBACHER
Affiliation:
Department of Epidemiology, German Centre for Research on Ageing, Heidelberg, Germany
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Abstract

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The aim of this analysis was to evaluate the effects of the presence of the IL-1RA gene polymorphism and H. pylori infection on markers of a systemic inflammatory response taking into account virulence markers of this infection. Serum concentrations of interleukin (IL)-6, IL-8, and tumour-necrosis factor (TNF)-α of 479 occasional blood donors were not statistically significantly higher in subjects having antibodies against H. pylori, or more specifically against CagA and VacA, and being homozygous for the pro-inflammatory IL-1RN*2 allele compared to others after adjustment for covariates. The findings suggest that the possible pro-inflammatory effect of the IL-1RN*2 allele in combination with H. pylori infection is limited to the mucosal level.

Type
Short Report
Information
Epidemiology & Infection , Volume 133 , Issue 3 , June 2005 , pp. 569 - 572
Copyright
© 2004 Cambridge University Press