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Growth of foot-and-mouth disease virus in the upper respiratory tract of non-immunized, vaccinated, and recovered cattle after intranasal inoculation

Published online by Cambridge University Press:  15 May 2009

J. W. McVicar  and
P. Sutmoller
J. W. McVicar
Affiliation:
Plum Island Animal Disease Center, Northeastern Region, Agricultural Research Service, U.S. Department of Agriculture, Greenport, L.I., New York 11944, U.S.A.
P. Sutmoller
Affiliation:
Plum Island Animal Disease Center, Northeastern Region, Agricultural Research Service, U.S. Department of Agriculture, Greenport, L.I., New York 11944, U.S.A.
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‘Mention of a trademark or a proprietary product does not constitute a guarantee or warranty of the product by the U.S. Department of Agriculture, and does not imply its approval to the exclusion of other products that may also be suitable.’

Non-immunized, vaccinated, and recovered cattle were inoculated intranasally with various doses of foot-and-mouth disease virus. Samples of oesophageal-pharyngeal (OP) fluid were taken periodically for up to 7 days after inoculation and virus titres of these samples were plotted as pharyngeal virus growth curves.

In non-immunized cattle, the length of the lag period and of the growth period were inversely proportional to the dose of virus given. Maximum titres were observed when clinical signs were first detected. Three of the 10 cattle studied had virus growth rates that were lower than rates of others given the same dose of virus, and clinical signs appeared later than expected in these three cattle.

Cattle vaccinated with an inactivated virus oil-adjuvant vaccine had pharyngeal virus growth curves that were similar to those obtained from non-immunized cattle for 30 h. after inoculation. Titres of virus in OP fluid samples taken 2–7 days after inoculation were substantially lower in cattle with a high pre-exposure serum mouse protection index than titres from partly-immunized or non-immunized cattle.

Nine of 14 recovered cattle had detectable but reduced virus growth after intranasal inoculation with homologous virus. Five recovered cattle inoculated with heterologous virus reacted similarly to non-immunized animals.

Type
Research Article
Information
Journal of Hygiene , Volume 76 , Issue 3 , June 1976 , pp. 467 - 481
Copyright
Copyright © Cambridge University Press 1976

References

REFERENCES

Bachrach, H. L., Callis, J. J., Hess, W. R., Patty, R. E., Deboer, C. J. & Hamblet, F. E. (1962). Large-scale production of bovine kidney cultures for plaque assay of foot-and-mouth disease virus and its ribonucleic acid. American Journal of Veterinary Research 23, 608.Google ScholarPubMed
Brown, F. & Cartwright, B. (1960). Purification of the virus of foot-and-mouth disease by fluorocarbon treatment and its dissociation from neutralizing antibody. Journal of Immunology 85, 309.Google Scholar
Burrows, R. (1966). Studies on the carrier state of cattle exposed to foot-and-mouth disease virus. Journal of Hygiene 64, 81.CrossRefGoogle ScholarPubMed
Burrows, R. (1968). Excretion of foot-and-mouth disease virus prior to the development of lesions. Veterinary Record 82, 387.Google Scholar
Burrows, R., Mann, J. A., Grieg, A., Chapman, W. G. & Goodridge, D. (1971). The growth and persistence of foot-and-mouth disease virus in the bovine mammary gland. Journal of Hygiene 69, 307.Google Scholar
Callis, J. J. & Cottral, G. E. (1968). Methods for containment of animal pathogens at the Plum Island Animal Disease Laboratory. In Methods in Virology ed. Maramorosch, K. and Koprowski, H., vol. IV. 465 pp. New York: Academic Press.Google Scholar
Cunha, R. G., Baptista, J. A. Jr, Serrao, U. M. & Torturella, I. (1957). El use de los ratones lactantes en la evaluacion de los anticurerpos contra el virus de la fiebre aftosa y su significacion immunologica. Gaceta Veterinaria 19, 243.Google Scholar
Donaldson, A. I., Herniman, K. A. J., Parker, J. & Sellers, R. F. (1970). Further investigations on the air-borne excretion of foot-and-mouth disease virus. Journal of Hygiene 68, 557.Google Scholar
Eskildsen, M. K. (1968). Experimental pulmonary foot-and-mouth disease infection of cattle. Report of the meeting of the Research Group of the Standing Technical Committee, European Commission Control of Foot-and-mouth Disease, Food and Agriculture Organization of the United Nations, Lindholm, Kalehave, Denmark 93,Google Scholar
Fogedby, E. G., Malmquist, W. A., Osteen, O. L. & Johnson, M. L. (1960). Air-borne transmission of foot-and-mouth disease virus. Nordisk Veterinaermedicin 12, 490.Google Scholar
Graves, J. H., McVicar, J. W., Sutmoller, P. & Trautman, R. (1971). Contact transmission of foot-and-mouth disease from infected to susceptible cattle. Journal of Infectious Diseases 123, 386.Google Scholar
Hyslop, N. St G. (1965 a). Secretions of foot-and-mouth disease virus and antibody in the saliva of infected and immunized cattle. Journal of Comparative Pathology 75, 111.Google Scholar
Hyslop, N. St G. (1965 b). Air-borne infection with the virus of foot-and-mouth disease. Journal of Comparative Pathology 75, 119.Google Scholar
McVicar, J. W., Graves, J. H. & Sutmoller, P. (1971). Growth of foot-and-mouth disease virus in the bovine pharynx. United States Animal Health Association Proceedings 74, 230.Google Scholar
McVicar, J. W. & Sutmoller, P. (1969). The epizootiological importance of foot-and-mouth disease carriers. II. The carrier status of cattle exposed to foot-and-mouth disease following vaccination with an oil adjuvant inactivated virus vaccine. Archiv für die gesamte Virusforschung 26, 217.Google Scholar
McVicar, J. W. & Sutmoller, P. (1974). Neutralizing activity in the serum and oesophageal-pharyngeal fluid of cattle after exposure to foot-and-mouth disease virus and subsequent re-exposure. Archiv für die gesamte Virusforschung 44, 173.CrossRefGoogle ScholarPubMed
McVicar, J. W., Sutmoller, P. & Andersen, A. A. (1974). Foot-and-mouth disease virus: plaque reduction neutralization test. Archiv für die gesamte Virusforschung 44, 168.CrossRefGoogle Scholar
Mirchamsy, H. & Rapp, F. (1968). A new overlay for plaquing animal viruses. Proceedings of the Society for Experimental Biology and Medicine 129, 13.Google Scholar
Sellers, R. F. & Parker, J. (1969). Air-borne excretion of foot-and-mouth disease virus. Journal of Hygiene 67, 671.Google Scholar
Sutmoller, P., Cottral, G. E. & McVicar, J. W. (1968). A review of the carrier state in foot-and-mouth disease. United States Livestock Sanitary Association Proceedings 71, 386.Google Scholar
Sutmoller, P. & McVicar, J. W. (1972). Foot-and-mouth disease: Changes in serum-neutralizing activity of immunized cattle shortly after virus exposure. Infection and Immunity 6, 718.CrossRefGoogle ScholarPubMed
Sutmoller, P. & McVicar, J. W. (1973). Foot-and-mouth disease: Growth of the virus after conjunctival inoculation of cattle. Archiv für die gesamte Virusforschung 43, 284.Google Scholar
Sutmoller, P., McVicar, J. W. & Cottral, G. E. (1968). The epizootiological importance of foot-and-mouth disease carriers. 1. Experimentally produced foot-and-mouth disease carriers in susceptible and immune cattle. Archiv für die gesamte Virusforschung 23, 227.Google Scholar
Vanbekkum, J. G., Frenkel, H. S., Frederiks, H. H. J. & Frenkel, S. (1959). Observations on the carrier state of cattle exposed to foot-and-mouth disease virus. Tijdschrift voor Diergeneeskunde 84, 1159.Google Scholar
VanBekkum, J. G., Straver, P. J., Bool, P. H. & Frenkel, S. (1966). Further information of the persistence of infective foot-and-mouth disease virus in cattle exposed to virulent virus strains. Bulletin, Office International des Épizooties 65, 1949.Google Scholar
Wagner, G. G., Card, J. L. & Cowan, K. M. (1970). Immunochemical studies of foot-and-mouth disease. VII. Characterization of foot-and-mouth disease virus concentrated by polyethylene glycol precipitation. Archiv für die gesamte Virusforschung 30, 343.CrossRefGoogle ScholarPubMed