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The growth and persistence of foot-and-mouth disease virus in the bovine mammary gland

Published online by Cambridge University Press:  15 May 2009

R. Burrows ,
J. A. Mann ,
A. Greig ,
W. G. Chapman  and
D. Goodridge
R. Burrows
Affiliation:
Animal Virus Research Institute, Pirbright, Surrey
J. A. Mann
Affiliation:
Animal Virus Research Institute, Pirbright, Surrey
A. Greig
Affiliation:
Animal Virus Research Institute, Pirbright, Surrey
W. G. Chapman
Affiliation:
Animal Virus Research Institute, Pirbright, Surrey
D. Goodridge
Affiliation:
Animal Virus Research Institute, Pirbright, Surrey
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In animals exposed to foot-and-mouth disease virus by indirect contact, virus was recovered from the blood, milk, pharynx, vagina and rectum for variable periods of time before clinical disease was apparent. Virus instilled into the mammary gland multiplied rapidly and virus concentrations greater than 107 p.f.u./ml. were recorded within 8–32 hr., depending on the virus strain and dose inoculated. Virus multiplication was accompanied by clinical signs of mastitis but the classical signs of foot-and-mouth disease did not appear for 52–117 hr. Dissemination of virus from the mammary gland occurred within 4–24 hr. and in some animals samples taken from the pharynx, mouth, nose and vagina contained virus for periods up to 97 hr. before the appearance of vesicular lesions. Virus production in the udder declined with the appearance of virus neutralizing activity in the blood and the milk but persisted in some animals for periods of 3–7 weeks. The ability of foot-and-mouth disease virus to persist in mammary tissue was confirmed by the demonstration of virus multiplication in the udders of immune animals.

Type
Research Article
Information
Journal of Hygiene , Volume 69 , Issue 2 , June 1971 , pp. 307 - 321
Copyright
Copyright © Cambridge University Press 1971

References

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