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Frequency of naturally occurring antibody to influenza virus antigenic variants selected in vitro with monoclonal antibody

Published online by Cambridge University Press:  25 March 2010

A. Natali ,
J. S. Oxford  and
G. C. Schild
A. Natali
Affiliation:
Institute of Microbiology, University of Parma, Italy
J. S. Oxford
Affiliation:
National Institute for Biological Standards and Control, Hampstead, London NW3
G. C. Schild
Affiliation:
National Institute for Biological Standards and Control, Hampstead, London NW3
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Summary

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Antigenic variants of A/Texas/77 (H3N2) virus were selected in vitro using monoclonal antibody to virus haemagglutinin (HA). The antigenic variants and parental A/Texas/77 viruses were used to evaluate the frequency of anti-HA antibodies in the sera of children and adults using single-radial-haemolysis (SRH) tests. Twenty to 41 % of selected sera from adults, which contained antibody to the parental A/Texas/77 virus, failed to react with the different antigenic mutant viruses. A higher proportion of sera from children (37–58%) failed to react with the antigenic variants. Certain human sera and particularly those of children would appear to possess a more limited antibody repertoire to influenza HA, potentially allowing new antigenic variants to escape neutralization and spread in the community.

Type
Research Article
Information
Journal of Hygiene , Volume 87 , Issue 2 , October 1981 , pp. 185 - 190
Copyright
Copyright © Cambridge University Press 1981

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