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Experimental encephalitis following peripheral inoculation of West Nile virus in mice of different ages

Published online by Cambridge University Press:  15 May 2009

Leslie P. Weiner ,
Gerald A. Cole  and
Neal Nathanson
Leslie P. Weiner
Affiliation:
Department of Epidemiology, School of Hygiene and Public Health, and Department of Neurology, School of Medicine, The Johns Hopkins University, Baltimore, Maryland 21205, U.S.A.
Gerald A. Cole
Affiliation:
Department of Epidemiology, School of Hygiene and Public Health, and Department of Neurology, School of Medicine, The Johns Hopkins University, Baltimore, Maryland 21205, U.S.A.
Neal Nathanson
Affiliation:
Department of Epidemiology, School of Hygiene and Public Health, and Department of Neurology, School of Medicine, The Johns Hopkins University, Baltimore, Maryland 21205, U.S.A.
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Summary

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Experimental arbovirus infections of mice provide a convenient model to study factors which determine the occurrence or severity of encephalitis following ex-traneural infection with certain neurotropic viruses. Varying doses of West Nile or Powassan viruses were inoculated by intraperitoneal or intramuscular routes into mice of varing ages; individual variables were manipulated to influence the outcome of infection. Three patterns of pathogenesis were delineated: (1) Fatal encephalitis, preceded by early viraemia, and invasion of the central nervous system. (2) In-apparent infection, with no detectable viraemia and no evidence of central nervous system invasion. (3) Subclinical encephalitis, usually preceded by trace viraemia, with minimal transient levels of virus in the brain. In this latter type of subclinical infection with a potentially lethal virus, the immune response probably plays an important role in recovery.

Type
Research Article
Information
Journal of Hygiene , Volume 68 , Issue 3 , September 1970 , pp. 435 - 446
Copyright
Copyright © Cambridge University Press 1970

References

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