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Evaluation of live attenuated measles vaccines prepared in human diploid cells for reimmunization

Published online by Cambridge University Press:  15 May 2009

H. Mirchamsy ,
A. Shafyi ,
P. Nazari ,
M. P. Ashtiani  and
A. Sassani
H. Mirchamsy
Affiliation:
Razi State Serum Institue, P.O. Box 11365—1558, Tehran, Islamic Republic of Iran
A. Shafyi
Affiliation:
Razi State Serum Institue, P.O. Box 11365—1558, Tehran, Islamic Republic of Iran
P. Nazari
Affiliation:
Razi State Serum Institue, P.O. Box 11365—1558, Tehran, Islamic Republic of Iran
M. P. Ashtiani
Affiliation:
Razi State Serum Institue, P.O. Box 11365—1558, Tehran, Islamic Republic of Iran
A. Sassani
Affiliation:
Razi State Serum Institue, P.O. Box 11365—1558, Tehran, Islamic Republic of Iran
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Two live attenuated measles vaccines developed in baby calf kidney cells, a similar vaccine produced in chick embryo chorioallantoic cells and five vaccines prepared from human diploid cells (HDC) have been studied by subcutaneous injection in groups of susceptible and immune children in three field trials. The results indicated that the vaccine developed in chick embryo cells which caused mild clinical reactions, had induced a lower seroprotection rate in susceptible children and only a low rise in hemagglutination-inhibition (HI) antibody titre in previously immunized children. The serological responses induced by vaccines developed in HDC or in calf kidney cells were satisfactory in both susceptible and immune children. The superiority of HDC grown measles vaccine for revaccination is discussed.

Type
Research Article
Information
Epidemiology & Infection , Volume 101 , Issue 2 , October 1988 , pp. 437 - 443
Copyright
Copyright © Cambridge University Press 1988

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