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Epidemiology of enteric adenovirus infection in prospectively monitored Argentine families

Published online by Cambridge University Press:  15 May 2009

A. S. Mistchenko ,
K. H. Huberman ,
J. A. Gomez  and
S. Grinstein
A. S. Mistchenko
Affiliation:
Laboratorio de Virología, Hospital de Niños ‘Ricardo Gutiérrez’, Gallo 1330, 1425 Buenos Aires, Argentina
K. H. Huberman
Affiliation:
Laboratorio de Virología, Hospital de Niños ‘Ricardo Gutiérrez’, Gallo 1330, 1425 Buenos Aires, Argentina
J. A. Gomez
Affiliation:
Laboratorio de Virología, Hospital de Niños ‘Ricardo Gutiérrez’, Gallo 1330, 1425 Buenos Aires, Argentina
S. Grinstein
Affiliation:
Laboratorio de Virología, Hospital de Niños ‘Ricardo Gutiérrez’, Gallo 1330, 1425 Buenos Aires, Argentina
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To examine the role of enteric adenoviruses (EAV) in an urban area of Buenos Aires (Argentina), we prospectively studied faecal samples from 49 families of newborns. These were monitored weekly for diarrhoea for 2 years.

A total of 180 samples from cases of diarrhoea and 766 samples obtained during diarrhoea-free periods were studied by dot-blot hybridization with an EAV-specific DNA probe. EAV were found in 6/180 (3·3%) cases of diarrhoea and 6/766 (0·8%) asymptomatic samples (P < 0·015). Incidence of EAV was 3·9 cases per 100 person-years in children < 60 months old. EAV-related diarrhoeas were slight and of short duration. In addition, 129 faeces from hospital out-patients, 1–30 months old, were also studied. EAV was identified in 7/129 cases (5·4%). These cases were 9·5 ±3·5 months old and the diarrhoea was mild or severe, of 3±1·5 days of duration.

We suggest that EAV are low-risk causes of diarrhoea under natural conditions, although a few children may develop more severe diarrhoea. The diagnosis of EAV needs to be considered in these patients.

Type
Research Article
Information
Epidemiology & Infection , Volume 109 , Issue 3 , December 1992 , pp. 539 - 546
Copyright
Copyright © Cambridge University Press 1992

References

REFERENCES

1.Uhnoo, I, Wadell, G, Svensson, L, Johansson, ME. Importance of enteric adenoviruses 40 and 41 in acute gastroenteritis in infants and young children. J Clin Microbiol 1984; 20: 365–72.Google Scholar
2.Vesikari, T, Maki, M, Sarkkinen, HJ, Arstila, PP, Halonen, PE. Rotavirus, adenovirus, and non-viral enteropathogens in diarrhea. Arch Dis Child 1981; 56: 264–70.CrossRefGoogle Scholar
3.Gary, GW Jr, Hierholzer, JC, Black, RE. Characteristics of noncultivatable adenoviruses associated with diarrhea in infants: a new subgroup of human adenoviruses. J Clin Microbiol 1979; 10: 96–103.CrossRefGoogle Scholar
4.Adrian, T, Schafer, G, Cooney, MK, Cox, JP, Wigand, R. Persistent enteral infections with adenovirus types 1 and 2 in infants: no evidence of reinfection. Epidemiol Infect 1988; 101: 311–14.CrossRefGoogle ScholarPubMed
5.Adrian, T, Wigand, R, Richter, J. Gastroenteritis in infants, associated with a genome type of adenovirus 31 and with combined rotavirus and adenovirus 31 infection. Eur J Pediatr 1987; 146: 38–40.Google Scholar
6.Johansson, ME, Uhnoo, I, Kidd, AH, Madeley, CR, Wadell, G. Direct identification of enteric adenovirus, a candidate new serotype. associated with infantile gastroenteritis. J Clin Microbiol 1980; 12: 95–100.CrossRefGoogle ScholarPubMed
7.Buitenwerf, J, Louwerens, JJ, De Jong, JC. A simple and rapid method for typing adenovirus 40 and 41 without cultivation. J Virol Meth 1985; 10: 39–44.CrossRefGoogle ScholarPubMed
8.Takiff, HE, Seidlin, M, Krause, P, et al. Detection of enteric adenovirus by dot-blot hybridization using a molecularly cloned viral DNA probe. J Med Virol 1985; 16: 107–18.CrossRefGoogle ScholarPubMed
9.Brandt, CD, Kim, HW, Rodriguez, WJ et al. . Adenoviruses and paediatric gastroenteritis. J Infect Dis 1985; 151: 437–43.Google Scholar
10.Kotloff, KL, Losonsky, GA, Morris, JG Jr, Wasserman, SS, Singh-Naz, N, Levine, MM. Enteric adenovirus infection and childhood diarrhea: An epidemiologic study in three clinical settings. Pediatrics 1989; 84: 219–25.CrossRefGoogle ScholarPubMed
11.Richmond, SJ, Wood, DJ, Bailey, AS. Recent respiratory and enteric adenovirus infections in children in the Manchester area. J R Soc Med 1988; 81: 15–18.CrossRefGoogle ScholarPubMed
12.Cevenini, R, Mazzaracchio, R, Rumpianes, F, et al. Prevalence of enteric adenovirus from acute gastroenteritis: a five year study. Eur J Epidemiol 1987; 3: 147–50.Google Scholar
13.Grinstein, S, Gomez, JA, Bercovich, JA, Biscotti, EL. Epidemiology of rotavirus infection and gastroenteritis in prospectively monitored Aregentine families with young children. Am J Epidemiol 1989; 130: 300–8.CrossRefGoogle Scholar
14.Leite, JPG, Pereira, HG, Azeredo, RS, Schatzmayr, HG. Adenovirus in faeces of children with acute gastroenteritis in Rio de Janeiro. Brazil. J Med Virol 1985; 15: 203–9.CrossRefGoogle ScholarPubMed
15.Pereira, HG, Valentine, R, Russell, W. Crystallization of an adenovirus protein (the hexon). Nature 1968; 219: 946–7.CrossRefGoogle ScholarPubMed
16.Hammond, G, Hannan, C, Yeh, T, Fischer, K, Mauthe, G, Straus, SE. DNA hybridization for diagnosis of enteric adenovirus infection from directly spotted human fecal specimens. J Clin Microbiol 1987; 25: 1881–5.CrossRefGoogle ScholarPubMed
17.Niel, C, Gomes, SA, Leite, JPG, Pereira, HG. Direct detection and differentiation of fastidious adenovirus in stools by using a specific nonradioactive probe. J Clin Microbiol 1986; 24: 785–9.CrossRefGoogle ScholarPubMed
18.Cardoso, DD, de Brito, WM, Martins, RM, et al. Ocurrência de rotavirus e adennovirus emamostras fecais de crianças com gastroenterite na cidade de Goiânia. Rev Soc Bras Med Trop 1989; 22: 67–71.Google Scholar
19.Herrmann, JE, Blacklow, NR, Perron-Henry, DM, Clements, E, Taylor, DN, Echeverria, P. Incidence of enteric adenovirus among children in Thailand and the significance of these viruses in gastroenteritis. J Clin Microbiol 1988; 26: 1783–6.CrossRefGoogle ScholarPubMed
20.Bhan, MK, Raj, P, Bhandari, N, et al. Role of enteric adenoviruses and rotaviruses in mild and severe acute enteritis. Pediatr Infect Dis J 1988; 7: 320–3.Google Scholar
21.Kim, KH, Yang, JM, Joo, SI, Cho, YG, Glass, RI, Cho, YJ. Importance of Rotavirus and Adenovirus types 40 and 41 in acute gastroenteritis in Korean children. J Clin Microbiol 1990; 28: 2279–84.Google Scholar
22.Rodriguez, WJ, Kim, HW, Brandt, CD, et al. Fecal adenoviruses from a longitudinal study of families in metropolitan Washington, DC.: Laboratory, clinical and epidemiological observations. J Pediatr 1985; 107: 514–20.Google Scholar
23.Cruz, JR, Cáceres, P, Cano, F, Flores, J, Bartlett, A, Torún, B. Adenovirus types 40 and 41 and rotavirus associated with diarrhoea in children from Guatemala. J Clin Microbiol 1990; 28: 1780–4.Google Scholar
24.Pavone, R, Schinaia, N, Harst, CA, Getty, B, Molyneux, M, Borgstein, A. Viral gastro-enteritis in children in Malawi. Ann Trop Paediatr 1990; 10: 15–20.Google Scholar
25.De Paerregaard, A, Hjelt, K, Genner, J, Moslet, U, Krasilnikoff, PA. Role of enteric adenoviruses in acute gastroenteritis in children attending day-care centers. Acta Paediatr Scand 1990; 79: 370–1.CrossRefGoogle Scholar
26.Uhnoo, I, Olding-Stenkvist, E, Kreuger, A. Clinical features of acute gastroenteritis associated with rotavirus, adenovirus and bacteria. Arch Dis Child 1986; 61: 732–8.Google Scholar
27.Shinozaki, T, Araki, K, Fujita, Y, Kobayashi, M, Tajima, T, Abe, T. Epidemiology of enteric adenovirus-40 and adenovirus-41 in acute gastroenteritis in infants and young children in the Tokyo area. Scand J Infect Dis 1991; 23: 543–7.Google Scholar
28.Tiemessen, CT, Negerhoff, FO, Erasmus, MJ, Kidd, AH. Infection by enteric adenoviruses, rotaviruses, and other agents in a rural African environment. J Med Virol 1989; 28: 176–82.CrossRefGoogle Scholar