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Electron-microscopic study of measles virus in lymphocytes of affected children

Published online by Cambridge University Press:  15 May 2009

H. K. Narang
H. K. Narang
Affiliation:
Medical Research Council Demyelinating Diseases Unit, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE
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Summary

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Two different types of inclusion bodies have been found by electron-microscopy in the cytoplasm of sectioned lymphocytes from children infected with measles.

The first is tubular, 18 nm. internal diameter, embedded in osmiophilic material, and is found during the incubation period. It is not thought to be specific for measles, and is probably identical with structures recently reported in HEp-2 cell lines and tumour tissue.

The second type is less obviously tubular and morphologically resembles measles nucleocapsid. This was found only after the rash had appeared.

Type
Research Article
Information
Journal of Hygiene , Volume 71 , Issue 3 , September 1973 , pp. 447 - 451
Copyright
Copyright © Cambridge University Press 1973

References

REFERENCES

Bell, T. M., Caspary, E. A., Cowshall, S., Field, E. J., Narang, H. K. & Noble, T. C. (1972). Measles virus associated with an unusual subacute encephalitis in an infant. Journal of the Neurological Sciences 16, 455.CrossRefGoogle ScholarPubMed
Berthiaume, L., & Joncas, J. (1973). Tubular structures in HEp-2 cell line. Journal of General Virology 18, 75.CrossRefGoogle ScholarPubMed
Clarke, J. K., Attridge, J. T. & Gay, F. W. (1969). The morphogenesis of simian foamy agents. Journal of General Virology 4, 183.CrossRefGoogle ScholarPubMed
Coulson, A. S. & Chalmers, D. G. (1967). Response of human blood lymphocytes to tuberculin PPD in tissue culture. Immunology 12, 417.Google ScholarPubMed
Daubney, R. (1928). Observations on Rinderpest. Journal of Comparative Pathology and Therapeutics 41, 228.CrossRefGoogle Scholar
Douglas, S. R. & Smith, W. (1930). A study of vaccinal immunity in rabbits by means of in vitro methods. British Journal of Experimental Pathology 11, 96.Google Scholar
Dunn, J. & Kernohan, J. W. (1957). Gliomatosis cerebri. Archives of Pathology 64, 82.Google ScholarPubMed
Fenner, F. & Woodroofe, G. (1953). The pathogenesis of infectious myxomatosis: response in the European rabbit (Oryctolagus cuniculus). British Journal of Experimental Pathology 34, 400.Google ScholarPubMed
Field, E. J. & Caspary, E. A. (1971). Demonstration of sentitized lymphocytes in blood. Journal of Clinical Pathology 24, 179.CrossRefGoogle Scholar
Field, E. J., Caspary, E. A., Shenton, B. K. & Madgwick, H. (1973). Lymphocyte sensitization after exposure to measles, and influenza; possible relevance to pathogenesis of multiple sclerosis. Journal of the Neurological Sciences (in the Press).CrossRefGoogle ScholarPubMed
Gresser, I. & Chany, C. (1963). Isolation of measles virus from the washed leucocytic fraction of blood. Proceedings of the Society for Experimental Biology and Medicine 113, 695.CrossRefGoogle ScholarPubMed
Hughes, D. & Caspary, E. A. (1970). Lymphocyte transformation in vitro measured by tritiated thymidine uptake. International Archives of Allergy and Applied Immunology 37, 506.CrossRefGoogle ScholarPubMed
von Pirquet, C. E. (1908). Das Verhalten der kutanen Tuberkulinreaktion während der Masern. Deutsche Medizinische Wochenschrift 34, 1297.CrossRefGoogle Scholar
Narang, H. K., Bell, T. M. & Gibson, P. E. (1971). Virus-like particles in L5178Y murine leukaemie cells. European Journal of Cancer 7, 325.CrossRefGoogle Scholar
Smith, W. (1929). The distribution of virus and neutralizing antibodies in the blood and pathological exudates of rabbits infected with vaccinia. British Journal of Experimental Pathology 10, 93.Google Scholar
Todd, C. (1928). Experiments on the virus of Fowl Plague (I). British Journal of Experimental Pathology 9, 19.Google Scholar