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Effect of various oral dose levels of a trimethoprim/sulphadiazine mixture on Bordetella bronchiseptica infection and on the proliferation of trimethoprim-resistant faecal coliforms in pigs

Published online by Cambridge University Press:  19 October 2009

L. Dassanayake  and
G. White
L. Dassanayake
Affiliation:
Wellcome Research Laboratories, Berkhamsted Hill, Berkhamsled HP4 2QE
G. White
Affiliation:
Wellcome Research Laboratories, Berkhamsted Hill, Berkhamsled HP4 2QE
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When a 1:5 mixture of trimethoprim (TMP) and sulphadiazine was fed to pigs intra-nasally infected with Bordetella bronchiseptica, 10 mg/kg/day was shown to be highly effective in suppressing the organism. This dose level had little effect on numbers of TMP-resistant coliforms in faeces, but oral doses of 30 mg/kg/day eventually selected a resistant population. It is suggested that the proliferation of resistant coliforms would be minimized by administration of the lowest oral dose rates of antibacterial drugs compatible with efficacy.

Type
Research Article
Information
Journal of Hygiene , Volume 90 , Issue 1 , February 1983 , pp. 41 - 47
Copyright
Copyright © Cambridge University Press 1983

References

REFERENCES

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