Hostname: page-component-76fb5796d-x4r87 Total loading time: 0 Render date: 2024-04-26T17:53:27.028Z Has data issue: false hasContentIssue false
  • English
  • Français

The effect of vaccination regimen on the transfer of foot and mouth disease antibodies from the sow to her piglets

Published online by Cambridge University Press:  19 October 2009

M. J. Francis  and
L. Black
M. J. Francis
Affiliation:
Wellcome Biotechnology Limited, Wellcome Foot and Mouth Disease Vaccine Laboratory, Ash Road, Pirbright, Surrey
L. Black
Affiliation:
Wellcome Biotechnology Limited, Wellcome Foot and Mouth Disease Vaccine Laboratory, Ash Road, Pirbright, Surrey
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Four groups of pregnant sows were inoculated with type O1 foot and mouth disease (FMD) oil emulsion vaccine at various times before farrowing and samples of the sow's serum, colostrum and milk, and piglet's serum, collected during the first week after farrowing, were analysed for FMD virus neutralizing activity.

No FMD neutralizing antibodies were detectable in the piglets serum at birth but they were present 1·5 h after suckling and peak titres were reached 1–3 days later. There was no significant difference between the antibody titres of colostrum samples collected from different teats at farrowing. However, similar samples collected 3 days later showed significant (P < 0·005) fore to hind variation. The principal FMD virus neutralizing antibody class present in the sow's serum at farrowing and in their 3-day-old piglets was governed by the inoculation schedule employed. When the last vaccinations were given ≃ 30 days before farrowing (dbf) the predominant FMD virus neutralizing class was IgG. However, when the sows were vaccinated only ≃ 12 dbf the predominant class was IgM. A significant correlation was observed between the sow's serum titres and colostrum titres at farrowing (r = 0·90), and also between sows colostrum titres at farrowing and their 3-day-old piglets serum titres (r = 0·99).

Type
Research Article
Information
Journal of Hygiene , Volume 93 , Issue 1 , August 1984 , pp. 123 - 131
Copyright
Copyright © Cambridge University Press 1984

References

REFERENCES

Anderson, E.C, Masters, R. C. & Mowat, G. N. (1971). Immune response of pigs to inactivated foot and mouth disease vaccines – Response to emulsion vaccines. Research in Veterinary Science 12, 342–350.CrossRefGoogle ScholarPubMed
Bourne, F. J. (1971). Porcine Immunoglobulins. Veterinary Annual 12, 74–85.Google Scholar
Bourne, F. J., Curtis, J., Johnson, R. H. & Collings, D. F. (1974). Antibody formation in porcine fetuses. Research in Veterinary Science 16, 223–227.CrossRefGoogle ScholarPubMed
Brambell, F. W. R. (1958). Pre-natal transference of antibodies. Veterinary Record 70, 1060–1063.Google Scholar
Brown, P. (1976). The Immune System of the Young Pig. Agricultural research seminar on porcine immunology (EVR 5450), p. 60–64.Google Scholar
Curtis, J. & Bourne, F. J. (1971). Immunoglobulin quantitation in sow serum, colostrum and milk and the serum of young pigs. Biochimica et Diophysica acta 236, 319–332.CrossRefGoogle ScholarPubMed
Curtis, J. & Bourne, F. J. (1973). Half lives of immunoglobulins IgG, IgA and IgM in the serum of new born pigs. Immunology 24, 147–155.Google ScholarPubMed
Dujin, T. (1971). Contribution to the knowledge of immunobiological protection of piglets against foot and mouth disease. Acta Veterinaria Beograd 21, 111–119.Google Scholar
Francis, M. J. & Black, L. (1983). Antibody response in pig nasal fluid and serum following foot and mouth disease infection or vaccination. Journal of Hygiene 91, 329–334.CrossRefGoogle ScholarPubMed
Francis, M. J. & Black, L. (1984). The effect of sows vaccination regimen on the decay rate of maternally derived foot and mouth disease antibodies in piglets. Research in Veterinary Science 37 (in the press.)CrossRefGoogle ScholarPubMed
Francis, M. J., Ouldridge, E. J. & Black, L. (1983). Antibody response in bovine pharyngeal fluid following foot and mouth disease vaccination and, or exposure to live virus. Research in Veterinary Science 35, 206–210.CrossRefGoogle ScholarPubMed
Kim, Y. B., Bradley, S. G. & Watson, D. W. (1966). Ontogeny of the Immune Response. I. Development of immunoglobulin in germfree and conventional colostrum-deprived piglets. Journal of Immunology 97, 52–63.CrossRefGoogle ScholarPubMed
Lecce, J. G. & Morgan, D. O. (1962). Effect of dietary regimen on cessation of intestinal absorption of large molecules (closure) in the neo-natal pig and lamb. Journal of Nutrition 78, 263–268.CrossRefGoogle Scholar
McKercher, P. D. & Giordano, A. R. (1967). Foot and mouth disease in swine. II. Some physical-chemical characteristics of antibodies produced by chemically treated and non-treated foot and mouth disease virus. Archiv fur die Gesamle Virusforschung 20, 54–70.CrossRefGoogle ScholarPubMed
Ouldridge, E. J., Francis, M. J. & Black, L. (1982). Antibody response of pigs to foot and mouth disease oil emulsion vaccine: the antibody classes involved. Research in Veterinary Science 32, 327–331.CrossRefGoogle ScholarPubMed
Perry, G. C. & Watson, J. H. (1967). Variation in the absorption of colostrally secreted marker antibody in piglets. Animal Production 9, 385–391.Google Scholar
Porter, P. (1969). Transfer of immunoglobulins IgG, IgA and IgM to lacteal secretions in the parturient sow and their absorption by the neonatal piglet. Biochimica et Biophysica Acta 181, 381–392.CrossRefGoogle ScholarPubMed
Porter, P. & Hill, I. R. (1970). Serological changes in immunoglobulins IgG, IgA and IgM and Escherichia coli antibodies in the young pig. Immunology 18, 565–573.Google ScholarPubMed
Yabiki, T., Kashiwazaki, M. & Namioka, S. (1974). Quantitative analysis of three classes of immunoglobulins in serum of newborn pigs and milk of sows. American Journal of Veterinary Research 35, 1483–1489.Google ScholarPubMed