Hostname: page-component-76fb5796d-x4r87 Total loading time: 0 Render date: 2024-04-26T09:20:32.627Z Has data issue: false hasContentIssue false
  • English
  • Français

Distribution and titres of rotavirus antibodies in different age groups

Published online by Cambridge University Press:  15 May 2009

M. M. Elias
M. M. Elias
Affiliation:
Regional Virus Laboratory, East Birmingham Hospital, Birmingham, B9 5ST
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Three hundred and fifty-seven sera selected at random from hospital patients of all ages were examined for rotavirus antibodies using indirect immunofluorescence (FA) and complement fixation tests (CFT). Three hundred and fourteen of these were also tested for neutralizing antibodies to human rotavirus. Sera from patients admitted with a diagnosis of acute gastroenteritis were excluded from this survey.

FA antibodies were found in newborn infants but fell to undetectable titres at 3 months. The highest titres were found in children between the ages of one and three years. In older age groups, the modal titre fell gradually with increasing age until, in sera from those above 70 years of age, FA antibodies were almost undetectable. The same pattern was observed with neutralizing antibodies. A high modal titre of CF antibodies was only found in sera from those aged one to three years.

Type
Research Article
Information
Journal of Hygiene , Volume 79 , Issue 3 , December 1977 , pp. 365 - 372
Copyright
Copyright © Cambridge University Press 1977

References

REFERENCES

Banatvala, J. E., Totterdell, B., Chrystie, I. L. & Woode, G. N. (1975). In vitro detection of human rotaviruses. Lancet ii, 821.CrossRefGoogle Scholar
Blacklow, N. R., Echeverria, P. & Smith, D. H. (1976). Serological studies with reovirus-like enteritis agent. Infection and Immunity 13, 1563–6.CrossRefGoogle ScholarPubMed
Bryden, A. S., Davies, H. A., Thouless, M. E. & Flewett, T. H. (1977). Diagnosis of rotavirus infection by cell culture. Journal of Medical Microbiology 10, 121–5.CrossRefGoogle ScholarPubMed
Flewett, T. H., Bryden, A. S., Davies, H., Woode, G. N., Bridger, J. C. & Derrick, J. M. (1974). Relation between viruses from acute gastroenteritis of children and newborn calves. Lancet ii, 61–3.CrossRefGoogle Scholar
Kapikian, A. Z., Cline, W. L., Kim, H. W., Kalica, A. R., Wyatt, R. G., Vankirk, D. H., Chanock, R. M., James, H. D. & Vaughan, A. L. (1976a). Antigenic relationships among five reovirus-like (RVL) agents by complement fixation (CF) and development of new substitute CF antigens for the human RVL agent of infantile gastroenteritis. Proceedings of the Society for Experimental Biology and Medicine 152, 535–9.CrossRefGoogle ScholarPubMed
Kapikian, A. Z., Cline, W. L., Mebus, C. A., Wyatt, R. G., Kalica, A. R., Chanock, R. M. & Kim, H. W. (1975). New complement fixation test for the human reovirus-like agent of infantile gastroenteritis. Lancet i, 1056–60.CrossRefGoogle Scholar
Kapikian, A. Z., Kim, H. W., Wyatt, R. G., Cline, W. L., Arrobio, J. O., Brandt, C. D., Rodriguez, W. J., Sack, D. A., Chanock, R. M. & Parrott, R. H. (1976b). Human reovirus-like agent as the major pathogen associated with winter gastroenteritis in hospitalized infants and young children. New England Journal of Medicine 294, 965–72.CrossRefGoogle ScholarPubMed
Mebus, C. A., Kono, M., Uneerdahl, N. R. & Twiehaus, M. J. (1971). Cell culture propagation of neonatal calf diarrhoea (scours) virus. Canadian Veterinary Journal 12, 69–72.Google ScholarPubMed
Middleton, P. J., Szymanski, M. T., Abbott, G. D., Bortolussi, R. & Hamilton, J. R. (1974). Orbivirus acute gastroenteritis of infancy, Lancet i, 1241–4.CrossRefGoogle Scholar
Ørstavjk, I., Figenschau, K. J., Haug, K. W. & Ulstrup, J. C. (1976). A reovirus-like agent (rotavirus) in gastroenteritis of children. Virus detection and serological studies. Scandinavian Journal of Infectious Diseases 8, 1–5.Google Scholar
Shepherd, R. W., Truslow, S., Bird, R., Cutting, W., Darnell, R. & Barker, C. M. (1975). Infantile gastroenteritis: a clinical study of reovirus-like agent infection. Lancet ii, 1082–3.CrossRefGoogle Scholar
Thouless, M. E., Bryden, A. S., Flewett, T. H., Woode, G. N., Bridger, J. C., Snodgrass, D. R. & Herring, J. A. (1977). Serological relationships between rotaviruses from different species as studied by complement fixation and neutralization. Archives of Virology 53, 287–94.CrossRefGoogle ScholarPubMed
Woode, G. N., Bridger, J. C., Jones, J. M., Flewett, T. H., Bryden, A. S., Davies, H. A. & White, G. B. B. (1976). Morphological and antigenic relationships between virus (Rota-viruses) from actute gastroenteritis of children, calves, piglets, mice and goats. Infection and Immunity 14, 804–10.CrossRefGoogle Scholar
Wyatt, R. G., Kapikian, A. Z., Thornhill, T. S., Sereno, M. M., Kim, H. W. & Chanock, R. M. (1974). In vitro cultivation in human fetal intestinal organ culture of a reovirus-like agent associated with non-bacterial gastroenteritis in infants and children. Journal of Infectious Diseases 130, 523–8.CrossRefGoogle Scholar