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The diagnosis and treatment of Helicobacter pylori infection in Arctic regions with a high prevalence of infection: Expert Commentary

  • B. J. McMAHON (a1) (a2), M. G. BRUCE (a2), A. KOCH (a3), K. J. GOODMAN (a4), V. TSUKANOV (a5), G. MULVAD (a6), M. L. BORRESEN (a3), F. SACCO (a1), D. BARRETT (a1), S. WESTBY (a1) and A. J. PARKINSON (a2)...

Summary

Helicobacter pylori infection is a major cause of peptic ulcer and is also associated with chronic gastritis, mucosa-associated lymphoid tissue (MALT) lymphoma, and adenocarcinoma of the stomach. Guidelines have been developed in the United States and Europe (areas with low prevalence) for the diagnosis and management of this infection, including the recommendation to ‘test and treat’ those with dyspepsia. A group of international experts performed a targeted literature review and formulated an expert opinion for evidenced-based benefits and harms for screening and treatment of H. pylori in high-prevalence countries. They concluded that in Arctic countries where H. pylori prevalence exceeds 60%, treatment of persons with H. pylori infection should be limited only to instances where there is strong evidence of direct benefit in reduction of morbidity and mortality, associated peptic ulcer disease and MALT lymphoma and that the test-and-treat strategy may not be beneficial for those with dyspepsia.

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Copyright

This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.

Corresponding author

* Author for correspondence: M. G. Bruce, MD, MPH, Epidemiology Team Leader, Arctic Investigations Program, Division of Preparedness and Emerging Infections, National Center for Emerging and Zoonotic Infectious Disease, Centers for Disease Prevention & Control, Anchorage, Alaska, 907 729 3416, USA. (Email: zwa8@cdc.gov)

References

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Epidemiology & Infection
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