Determinants of case fatality rates of meningococcal disease during outbreaks in Makkah, Saudi Arabia, 1987–97

H. E. EL BUSHRA; N. M. M. HASSAN; N. A. AL-HAMDAN; M. H. AL-JEFFRI; A. M. TURKISTANI; A. AL-JUMAILY; M. A. ALI; A. M. RAHAMA

doi:10.1017/S0950268800004805

Abstract

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We studied case-fatality rates (CFRs) among cases of meningococcal disease (MCD) admitted to Makkah (Saudi Arabia) hospitals during the period 1988–97. Of 483 cases, 431 (89·2%) were due to strains of serogroup A, 31 (6·4%) to serogroup W135, 16 (3·3%) to serogroup C, and 5 (1·0%) to serogroup B. Eighty-one patients died (case fatality rate (CFR)) 16·8%, 95% CI 13·5%, 20·4%). The CFR in infections due to serogroup A strains was 14·8%, and for other serogroups it was 32·7% (95% CI 20·3%, 47·1%). The CFR of MCD due to N. meningitidis serogroup A increased steadily with age (P < 0·05). Seeking first medical help at a foreign Hajj medical mission and being treated in a non-specialized hospital were associated with a higher case fatality rate.

Crossref Citations

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Memish, Z. A. 2002. Meningococcal Disease and Travel. Clinical Infectious Diseases, Vol. 34, Issue. 1, p. 84.

Balkhy, Hanan H. Memish, Ziad A. and Osoba, Abimbola O. 2003. Meningococcal carriage among local inhabitants during the pilgrimage 2000–2001. International Journal of Antimicrobial Agents, Vol. 21, Issue. 2, p. 107.

Memish, Ziad A. and Ahmed, Qanta A. A. 2006. Mecca Bound: The Challenges Ahead. Journal of Travel Medicine, Vol. 9, Issue. 4, p. 202.

Faustini, Annunziata Arca’, Massimo Fusco, Danilo and Perucci, Carlo A. 2007. Prognostic factors and determinants of fatal outcome due to bacterial meningitis in the Lazio region of Italy, 1996–2000. International Journal of Infectious Diseases, Vol. 11, Issue. 2, p. 137.

Khalil, Mohamed K.M. and Borrow, Ray 2009. Serogroup B meningococcal disease during Hajj: Preparing for the worst scenario. Travel Medicine and Infectious Disease, Vol. 7, Issue. 4, p. 231.

Al‐Tawfiq, Jaffar A. Clark, Thomas A. and Memish, Ziad A. 2010. Meningococcal Disease: The Organism, Clinical Presentation, and Worldwide Epidemiology. Journal of Travel Medicine, Vol. 17, Issue. suppl 1, p. 3.

da Silva, Luiz Jacintho DeTora, Lisa Malerczyk, Claudius and Memish, Ziad A 2012. Emergence ofNeisseria meningitidisW-135 in the context of other rare serogroups. Clinical Investigation, Vol. 2, Issue. 2, p. 177.

Yezli, Saber Bin Saeed, Abdulaziz A. Assiri, Abdullah M. Alhakeem, Rafat F. Yunus, Muslim A. Turkistani, Abdulhafiz M. Booy, Robert and Alotaibi, Badriah M. 2016. Prevention of meningococcal disease during the Hajj and Umrah mass gatherings: past and current measures and future prospects. International Journal of Infectious Diseases, Vol. 47, Issue. , p. 71.

Yezli, Saber Assiri, Abdullah M. Alhakeem, Rafat F. Turkistani, Abdulhafiz M. and Alotaibi, Badriah 2016. Meningococcal disease during the Hajj and Umrah mass gatherings. International Journal of Infectious Diseases, Vol. 47, Issue. , p. 60.

Yezli, Saber Wilder-Smith, Annelies and Bin Saeed, Abdulaziz A. 2016. Carriage of Neisseria meningitidis in the Hajj and Umrah mass gatherings. International Journal of Infectious Diseases, Vol. 47, Issue. , p. 65.

Mustapha, Mustapha M. Marsh, Jane W. and Harrison, Lee H. 2016. Global epidemiology of capsular group W meningococcal disease (1970–2015): Multifocal emergence and persistence of hypervirulent sequence type (ST)-11 clonal complex. Vaccine, Vol. 34, Issue. 13, p. 1515.

Yezli, Saber 2018. The threat of meningococcal disease during the Hajj and Umrah mass gatherings: A comprehensive review. Travel Medicine and Infectious Disease, Vol. 24, Issue. , p. 51.

Sebastian, Sergerard Badahdah, Al-Mamoon Khatami, Ameneh and Rashid, Harunor 2020. Handbook of Healthcare in the Arab World. p. 1.

Sebastian, Sergerard Badahdah, Al-Mamoon Khatami, Ameneh and Rashid, Harunor 2021. Handbook of Healthcare in the Arab World. p. 1289.

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Determinants of case fatality rates of meningococcal disease during outbreaks in Makkah, Saudi Arabia, 1987–97

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