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Contamination of fluids from a hospital pharmacy

  • D. H. M. Joynson (a1), C. H. L. Howells (a1), R. Liddington (a1) and A. Williams (a2)

Summary

An investigation into the cause of bacterial contamination of bottles of non-injectable water has been reported. A method of monitoring such bottles has also been described. The roles played by autoclave spray-cooling water and inadequate bottle seals in the contamination of fluids have been examined. Possible methods of reducing the risk of contamination are discussed and the design of an improved method of closure of sterile bottled fluids is stressed. Bacteriological examination is shown to be a more accurate index of the true rate of contamination than measurement of dye concentrations of bottle contents.

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References

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Beverly, S., Hambleton, R. & Aliwood, M. C. (1974). Leakage of spray cooling water into topical water bottles. Pharmaceutical Journal 212, 306.
Duma, R. J., Warner, J. F. & Dalton, H. P. (1971). Septicaemia from intravenous infusions. New England Journal of Medicine. 284, 257.
Felts, S. K., Schaffner, W., Melly, M. A. & Koenig, M. G. (1972). Sepsis caused by contaminated intravenous fluids. Annals of Internal Medicine 77, 881.
Meers, P. D., Calder, M. W., Mazhar, M. M. & Lawrie, G. M. (1973). Intravenous infusion of contaminated dextrose solution. Lancet ii, 1189.
Marshall, J. H. & Kelsey, J. C. (1970). A standard culture medium for general bacteriology. Journal of Hygiene 58, 367.
Medicines Commission Report (1972).
Phillips, I., Eykym, S. & Laber, M. (1972). Outbreak of hospital infection caused by contaminated autoclaved fluids. Lancet i, 1258.

Contamination of fluids from a hospital pharmacy

  • D. H. M. Joynson (a1), C. H. L. Howells (a1), R. Liddington (a1) and A. Williams (a2)

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