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A comparative clinical study of Adsorbed Tetanus Vaccine and Adult-type Tetanus–Diphtheria Vaccine

Published online by Cambridge University Press:  25 March 2010

S. P. Deacon ,
D. T. Langford ,
W. M. Shepherd  and
P. A. Knight
S. P. Deacon
Affiliation:
Occupational Health Physician, ICI Petrochemicals Division, Middlesbrough
D. T. Langford
Affiliation:
Departments of Clinical Immunology and Bacterial Products Quality Control The Wellcome Research Laboratories, Beckenham
W. M. Shepherd
Affiliation:
Departments of Clinical Immunology and Bacterial Products Quality Control The Wellcome Research Laboratories, Beckenham
P. A. Knight
Affiliation:
Departments of Clinical Immunology and Bacterial Products Quality Control The Wellcome Research Laboratories, Beckenham
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Summary

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A limited assessment of immunity to diphtheria revealed that only 44·8 % of adults had protective levels (> 0·01 U/ml) of diphtheria antitoxin in their sera. In the light of this information, it was decided to assess the suitability of Adult-type Tetanus-Diphtheria Vaccine as a replacement for Adsorbed Tetanus Vaccine in occupational health schemes. A comparative study of these vaccines showed that a single dose of each produced an equivalent rate and level of tetanus antitoxin responses. Adult-type Td Vaccine elicited more than fourfold increases of diphtheria antitoxin in 76 % of vaccinees. No statistically significant differences were observed in the clinical reactivity of the vaccines under test. However, the combined vaccine caused a slightly higher incidence of local reactions (pain, redness and swelling) while recipients of Adsorbed Tetanus Vaccine more frequently experienced pain.

Type
Research Article
Information
Journal of Hygiene , Volume 89 , Issue 3 , December 1982 , pp. 513 - 519
Copyright
Copyright © Cambridge University Press 1982

References

REFERENCES

Ad-Hoc Working Group (1978). Susceptibility to diphtheria. The Lancet i, 428–430.Google Scholar
Collier, L. H., Polakoff, S. & Mortimer, J. (1979). Reactions and antibody responses to reinforcing doses of adsorbed and plain Tetanus vaccines. The Lancet i, 1364–1368.CrossRefGoogle Scholar
David, D. & Zehntner, B. (1971). Tetanusimpfung: Nebenevirkungen bei verschiedenen impflokalisationen und Modus. Sweitzerische Medizinische Worchenschrift 101, 1055–1057.Google Scholar
Edsall, G., Altman, J. S. & Gaspar, A. J. (1954). Combined tetanus – diphtheria immunization of adults: use of small doses of diphtheria toxoid. American Journal of Public Health 44, 1537–1545.CrossRefGoogle ScholarPubMed
Glenny, A. T. & Allen, K. (1921). The testing of diphtheria toxin and antitoxin by intracutaneous injection into guinea pigs. Journal of Pathology and Bacteriology 24, 61–63.CrossRefGoogle Scholar
Glenny, A. T. & Stevens, M. F. (1938). The laboratory control of tetanus prophylaxis. Journal of the Royal Army Medical Corps. 70, 308–310.Google Scholar
Holt, L. B. & Bousfield, S. (1949). P.T.A.P.: the present position. British Medical Journal 1, 695–699.Google Scholar
Ipsen, J. (1954). Immunisation of adults against diphtheria and tetanus. New England Journal of Medicine 251, 459–466.CrossRefGoogle ScholarPubMed
McCloskey, R. V. (1969). Diphtheria antitoxin titres in hospital workers after a single dose of Adult-type Td Diphtheria Tetanus Toxoid. American Journal of Medical Science 258, 209–213.Google Scholar
Mitchell, R. & Barr, A. (1978). Immunisation of adults against diphtheria. British Medical Journal ii, 1371–1372.CrossRefGoogle Scholar
Pappenheimer, A.M., Edsall, G., Lawrence, H. S. & Banton, H. J. (1950). A study of reactions following administration of crude and purified diphtheria toxoid in an adult population. American Journal of Hygiene 52, 353–370.Google Scholar
Ruben, F. I., Nagel, J. & Fireman, P. L. (1978). Antitoxin responses in the elderly to tetanus diphtheria (Td) immunisation. American Journal of Epidemiology 108, 145–149.CrossRefGoogle Scholar
Scheibel, I., Bentzon, M. W.Christensen, P. E. (1966). Duration of immunity to diphtheria and tetanus after active immunisation. Acta Pathologica et Microbiologica, Scandinavia 67, 380–392.CrossRefGoogle Scholar
Sheffield, F. W., Ironside, A. G. & Abbott, J. D. (1978). Immunisation of adults against diphtheria. British Medical Journal ii, 249–250.CrossRefGoogle Scholar
White, W. G., Barnes, G. M., Barker, E.Gall, D., Knight, P., Griffith, A. H., Morris-Owen, R. M. & Smith, J. W. G. (1973). Reactions to tetanus toxoid. Journal of Hygiene, 71, 283–297.CrossRefGoogle ScholarPubMed
White, W. G. (1980). Reactions after plain and adsorbed tetanus vaccines. Lancet i, 42.CrossRefGoogle Scholar