Skip to main content Accessibility help
×
Home

A comparative clinical study of Adsorbed Tetanus Vaccine and Adult-type Tetanus–Diphtheria Vaccine

  • S. P. Deacon (a1), D. T. Langford (a2), W. M. Shepherd (a2) and P. A. Knight (a2)

Summary

A limited assessment of immunity to diphtheria revealed that only 44·8 % of adults had protective levels (> 0·01 U/ml) of diphtheria antitoxin in their sera. In the light of this information, it was decided to assess the suitability of Adult-type Tetanus-Diphtheria Vaccine as a replacement for Adsorbed Tetanus Vaccine in occupational health schemes. A comparative study of these vaccines showed that a single dose of each produced an equivalent rate and level of tetanus antitoxin responses. Adult-type Td Vaccine elicited more than fourfold increases of diphtheria antitoxin in 76 % of vaccinees. No statistically significant differences were observed in the clinical reactivity of the vaccines under test. However, the combined vaccine caused a slightly higher incidence of local reactions (pain, redness and swelling) while recipients of Adsorbed Tetanus Vaccine more frequently experienced pain.

    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      A comparative clinical study of Adsorbed Tetanus Vaccine and Adult-type Tetanus–Diphtheria Vaccine
      Available formats
      ×

      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      A comparative clinical study of Adsorbed Tetanus Vaccine and Adult-type Tetanus–Diphtheria Vaccine
      Available formats
      ×

      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      A comparative clinical study of Adsorbed Tetanus Vaccine and Adult-type Tetanus–Diphtheria Vaccine
      Available formats
      ×

Copyright

References

Hide All
Ad-Hoc Working Group (1978). Susceptibility to diphtheria. The Lancet i, 428430.
Collier, L. H., Polakoff, S. & Mortimer, J. (1979). Reactions and antibody responses to reinforcing doses of adsorbed and plain Tetanus vaccines. The Lancet i, 13641368.
David, D. & Zehntner, B. (1971). Tetanusimpfung: Nebenevirkungen bei verschiedenen impflokalisationen und Modus. Sweitzerische Medizinische Worchenschrift 101, 10551057.
Edsall, G., Altman, J. S. & Gaspar, A. J. (1954). Combined tetanus – diphtheria immunization of adults: use of small doses of diphtheria toxoid. American Journal of Public Health 44, 15371545.
Glenny, A. T. & Allen, K. (1921). The testing of diphtheria toxin and antitoxin by intracutaneous injection into guinea pigs. Journal of Pathology and Bacteriology 24, 6163.
Glenny, A. T. & Stevens, M. F. (1938). The laboratory control of tetanus prophylaxis. Journal of the Royal Army Medical Corps. 70, 308310.
Holt, L. B. & Bousfield, S. (1949). P.T.A.P.: the present position. British Medical Journal 1, 695699.
Ipsen, J. (1954). Immunisation of adults against diphtheria and tetanus. New England Journal of Medicine 251, 459466.
McCloskey, R. V. (1969). Diphtheria antitoxin titres in hospital workers after a single dose of Adult-type Td Diphtheria Tetanus Toxoid. American Journal of Medical Science 258, 209213.
Mitchell, R. & Barr, A. (1978). Immunisation of adults against diphtheria. British Medical Journal ii, 13711372.
Pappenheimer, A.M., Edsall, G., Lawrence, H. S. & Banton, H. J. (1950). A study of reactions following administration of crude and purified diphtheria toxoid in an adult population. American Journal of Hygiene 52, 353370.
Ruben, F. I., Nagel, J. & Fireman, P. L. (1978). Antitoxin responses in the elderly to tetanus diphtheria (Td) immunisation. American Journal of Epidemiology 108, 145149.
Scheibel, I., Bentzon, M. W.Christensen, P. E. (1966). Duration of immunity to diphtheria and tetanus after active immunisation. Acta Pathologica et Microbiologica, Scandinavia 67, 380392.
Sheffield, F. W., Ironside, A. G. & Abbott, J. D. (1978). Immunisation of adults against diphtheria. British Medical Journal ii, 249250.
White, W. G., Barnes, G. M., Barker, E.Gall, D., Knight, P., Griffith, A. H., Morris-Owen, R. M. & Smith, J. W. G. (1973). Reactions to tetanus toxoid. Journal of Hygiene, 71, 283297.
White, W. G. (1980). Reactions after plain and adsorbed tetanus vaccines. Lancet i, 42.

A comparative clinical study of Adsorbed Tetanus Vaccine and Adult-type Tetanus–Diphtheria Vaccine

  • S. P. Deacon (a1), D. T. Langford (a2), W. M. Shepherd (a2) and P. A. Knight (a2)

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed