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Combined pertussis-diphtheria prophylactic antigens: An experimental study to determine the specific immunizing value of these antigens used in combination

Published online by Cambridge University Press:  15 May 2009

David Ordman  and
E. Grasset
David Ordman
Affiliation:
From the South African Institute for Medical Research, Johannesburg
E. Grasset
Affiliation:
From the South African Institute for Medical Research, Johannesburg
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1. Experiments in laboratory animals are described, which were made to determine the specific antibody production following injections of diphtheria and pertussis antigens separately or in combination.

2. Agglutinins to H. pertussis vaccine were not increased or otherwise changed by combining H. pertussis vaccines with either diphtheria anatoxine or A.P.T.

3. A striking enhancement of diphtheria antitoxin production occurred when diphtheria prophylactics were used combined with pertussis vaccine. Such improvement in antitoxin production was most marked in the case of diphtheria anatoxine, but was also shown following the use of A.P.T. in combination with pertussis vaccine.

4. Diphtheria anatoxine combined with H. pertussis vaccine gave no better antitoxin response than did a.p.t. alone.

Type
Research Article
Information
Journal of Hygiene , Volume 46 , Issue 2 , July 1948 , pp. 117 - 122
Copyright
Copyright © Cambridge University Press 1948

References

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