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Clinical and immunological analysis of measles patients admitted to a Beijing hospital in 2014 during an outbreak in China

  • B. TU (a1) (a2), J.-J. ZHAO (a2), Y. HU (a2), J.-L. FU (a2), H-H. HUANG (a2), Y.-X. XIE (a2), X. ZHANG (a2), L. SHI (a2), P. ZHAO (a2), X.-W. ZHANG (a2), D. WU (a2), Z. XU (a2), Z.-P. ZHOU (a2), E.-Q. QIN (a2) and F.-S. WANG (a2)...

Summary

At the end of 2013, China reported a countrywide outbreak of measles. From January to May 2014, we investigated the clinical and immunological features of the cases of the outbreak admitted to our hospital. In this study, all 112 inpatients with clinically diagnosed measles were recruited from the 302 Military Hospital of China. The virus was isolated from throat swabs from these patients, and cytokine profiles were examined. By detecting the measles virus of 30 of the 112 patients, we found that this measles outbreak was of the H1 genotype, which is the major strain in China. The rates of complications, specifically pneumonia and liver injury, differed significantly in patients aged <8 months, 8 months to 18 years, and >18 years: pneumonia was more common in children, while liver injury was more common in adults. Pneumonia was a significant independent risk factor affecting measles duration. Compared to healthy subjects, measles patients had fewer CD4+IL-17+, CD4+IFN-γ +, and CD8+IFN-γ + cells in both the acute and recovery phases. In contrast, measles patients in the acute phase had more CD8+IL-22+ cells than those in recovery or healthy subjects. We recommend that future studies focus on the age-related distribution of pneumonia and liver injury as measles-related complications as well as the association between immunological markers and measles prognosis.

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Copyright

Corresponding author

*Author for correspondence: Dr E.-Q. Qin or Dr F.-S. Wang, Beijing 302 Hospital, 100 Western 4th Ring Middle Road, Beijing 100039, China. (Email: Qeq2004@sina.com) [E.-Q.Q.] (Email: Fswang302@163.com) [F.-S.W.]

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† These authors contributed equally to this work.

Footnotes

References

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1. World Healt Organization. Measles (http://www.who.int/mediacentre/factsheets/fs286/en/).
2. Wolfson, LJ, et al. Estimates of measles case fatality ratios: a comprehensive review of community-based studies. International Journal of Epidemiology 2009; 38: 192205.
3. Perry, RT, Halsey, NA. The clinical significance of measles: a review. Journal of Infectious Diseases 2004; 189 (Suppl. 1): S4–16.
4. Ma, C, et al. Monitoring progress towards the elimination of measles in China: an analysis of measles surveillance data. Bulletin of the World Health Organization 2014; 92: 340347.
5. Loukides, S, et al. Bacterial pneumonia as a suprainfection in young adults with measles. European Respiratory Journal 1999; 13: 356360.
6. Caseris, M, et al. French 2010–2011 measles outbreak in adults: report from a Parisian teaching hospital. Clinical Microbiology and Infection 2014; 20: O242244.
7. Ackerman, Z, et al. Hepatitis during measles in young adults: possible role of antipyretic drugs. Hepatology 1989; 10: 203206.
8. Fu, HY, et al. Retrospective study of risk factors of mortality in patients with measles in a tertiary pediatric hospital. Chinese Journal of Infectious Diseases 2013; 31: 598602.
9. Permar, SR, Griffin, DE, Letvin, NL. Immune containment and consequences of measles virus infection in healthy and immunocompromised individuals. Clinical and Vaccine Immunology 2006; 13: 437443.
10. Koga, R, et al. Measles virus-induced immunosuppression in SLAM knock-in mice. Journal of Virology 2010; 84: 53605367.
11. Sun, X, et al. Suppression of antigen-specific T cell proliferation by measles virus infection: role of a soluble factor in suppression. Virology 1998; 246: 2433.
12. Dagan, R, et al. Cellular immunity and T-lymphocyte subsets in young children with acute measles. Journal of Medical Virology 1987; 22: 175182.
13. Lv, QQ, Xu, WF. Expression of T lymphocyte and regulatory T lymphocyte in patients with measles. Disease Surveillance 2011; 26: 516518.
14. Jin, W, Dong, C. IL-17 cytokines in immunity and inflammation. Emerging Microbes & Infections 2013; 2: e60.
15. Pociask, DA, et al. IL-22 is essential for lung epithelial repair following influenza infection. American Journal of Pathology 2013; 182: 12861296.
16. Hijnen, D, et al. CD8(+) T cells in the lesional skin of atopic dermatitis and psoriasis patients are an important source of IFN-gamma, IL-13, IL-17, and IL-22. Journal of Investigative Dermatology 2013; 133: 973979.
17. Res, PC, et al. Overrepresentation of IL-17A and IL-22 producing CD8 T cells in lesional skin suggests their involvement in the pathogenesis of psoriasis. PLoS ONE 2010; 5: e14108.
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Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
  • URL: /core/journals/epidemiology-and-infection
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