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Clearance of antibiotics from the intestines after termination of antibiotic decontamination

  • D. van der Waaij (a1), J. E. C. Lekkerkerk-van der Wees (a1) and P. J. Heidt (a1)

Summary

The clearance of neomycin and kanamycin from the intestines after stopping oral supply has been determined in mice. Both antibiotics, although given in different doses, were excreted in essentially the same way; the clearance being a little faster than logarithmically in both cases. The importance of this observation with regard to isolation and the moment of reconventionalization is discussed.

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References

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Abrams, G. D. & Bishop, J. E. (1966). Effect of the normal microbial flora on the resistance of the small intestine to infection. Journal of Bacteriology 92, 1604.
Abrams, G. D. & Bishop, J. E. (1967). Effect of the normal microbial flora on gastrointestinal motility. Proceedings of the Society for Experimental Biology and Medicine 126, 301.
Goss, W. A. & Cimijotti, E. B. (1968). Evaluation of an automatic diluting device for microbiological applications. Applied Microbiology 16, 1414.
Waaij, D. van der, Vries, J. M. de & Lekkerkerk, J. E. C. (1970). Eliminating bacteria from monkeys with antibiotics. In: Infections and Immunosuppression in Subhuman Primates, p. 21. Copenhagen; Munksgard.
Waaij, D. van der & Andreas, A. H. (1971 a). Prevention of airborne contamination and cross-contamination in germ-free mice by laminar flow. Journal of Hygiene, 69, 83.
Waaij, D. van der, Berghuis-de Vries, J. M. & Lekkerkerk-Van der Wees, J. E. C. (1971 b). Colonization resistance of the digestive tract in conventional and antibiotic-treated mice. Journal of Hygiene 69, 405.
Waaij, D. van der, Vries, J. M. de & Lekkerkerk, J. E. C. (1972). Colonization resistance of the digestive tract and the spread of bacteria to the lymphatic organs in mice. Journal of Hygiene 70, 335.

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