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Class-specific herpes simplex virus antibodies in sera and cervical secretions from patients with cervical neoplasia: a multi-group comparison

Published online by Cambridge University Press:  19 October 2009

G. E. Dale ,
R. M. Coleman ,
J. M. Best ,
B. B. B. Benetato ,
N. C. Drew ,
S. Chinn ,
A. O. Papacosta  and
A. J. Nahmias
G. E. Dale*
Affiliation:
Departments of Virology
R. M. Coleman
Affiliation:
Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
J. M. Best
Affiliation:
Departments of Virology
B. B. B. Benetato
Affiliation:
Departments of Virology
N. C. Drew
Affiliation:
Obstetrics and Gynaecology
S. Chinn
Affiliation:
Community Medicine, The United Medical and Denial Schools of Guy's and St Thomas's Hospitals, St Thomas's Campus, London SE1 7EH, England
A. O. Papacosta
Affiliation:
Community Medicine, The United Medical and Denial Schools of Guy's and St Thomas's Hospitals, St Thomas's Campus, London SE1 7EH, England
A. J. Nahmias
Affiliation:
Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
*
Correspondence should be addressed to: G. E. Dale, Department of Virology. The United Medical and Dental Schools of Guy's and St Thomas's Hospitals, St Thomas's Campus. London SKI 7KH.
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Serum and cervical secretions were collected from patients with cervical dysplasia, carcinoma-in-situ (CIS), squamous cell carcinoma (cervical SCC), and controls with normal cervices, attending clinics within the West Lambeth Health District, London. Enzyme-linked immunosorbent assays were used to examine cervical secretory IgA (sIgA) and serum IgG and IgA antibodies to herpes simplex virus (HSV). Sexual and demographic factors were considered during data analysis, which involved fitting multiple linear or multiple logistic regressions to HSV antibody levels. Prevalence of sIgA-HSV and levels of serum antibodies to HSV in all groups were compared with those of gynaecology controls. Caucasian women with mild dysplasia had a significantly higher prevalence of sIgA-HSV. Serum IgG levels to HSV (IgG-HSV) were significantly elevated in women with mild dysplasia and severe dysplasia/ClS. Serum IgA levels to HSV1 (IgG-HSV1) were significantly higher in women with cervical SCC (after adjusting for smoking habits) and other genital tumours. Significantly higher levels of serum IgA to HSV2 (IgA-HSV2) were also found among Caucasian women with cervical SCC. The possible role of HSV as a co-factor in cervical carcinogenesis is discussed.

Type
Research Article
Information
Epidemiology & Infection , Volume 100 , Issue 3 , June 1988 , pp. 455 - 465
Copyright
Copyright © Cambridge University Press 1988

References

Baker, R. J. & Nelder, A. (1978). The GLIM system, release 3. Oxford: Numerical Algorithms Group.Google Scholar
Coleman, R. M., Peresira, L., Bailey, P. D., Dondero, D., Wickliffe, C. & Nahmias, A. J. (1983). Determination of herpes simplex virus type-specific antibodies by enzyme-linked immunosorbent assay. Journal of Clinical Microbiology 18, 287–291CrossRefGoogle ScholarPubMed
Dent, P. B. & Bienenstock, J. (1974). Absence of IgA antibody to herpesvirus in cervicovaginal secretions of patients with carcinoma of the cervix. Clinical Immunology and Immunopathology 3, 171–177.CrossRefGoogle ScholarPubMed
Graham, S., Rawls, W., Swanson, M. & McCurtis, J. (1982). Sex partners and herpes simplex virus type 2 in the epidemiology of cancer of the cervix. American Journal of Epidemiology 115, 729–735.CrossRefGoogle ScholarPubMed
Guinan, M. E., Wolinsky, S. M. & Reichman, R. C. (1985). Epidemiology of genital herpes simplex virus infection. Epidemiological Reviews 7, 127–146.CrossRefGoogle ScholarPubMed
Harris, R. W. C., Brinton, L. A., Cowdell, R. H., Skegg, D. C. G., Smith, P. G., Vessey, M. P. & Doll, R. (1980). Characteristics of women with dysplasia or carcinoma in situ of the cervix uteri. British Journal of Cancer 42, 359–368.CrossRefGoogle ScholarPubMed
Kalimo, K., Terho, P., Honkonen, E., Gronroos, M., Halonen, P. (1981). Chlamydia trachomatis and herpes simplex virus TgA antibodies in cervical secretions of patients with cervical atypia. British Journal of Obstetrics and Gynaecology 88, 1130–1134.CrossRefGoogle Scholar
Lycke, E., Norrby, R., Roos, B. E. (1974). A serological study of mentally ill patients with particular reference to the prevalenceoof herpes virus infections. British Journal of Psychiatry 124, 273–279.CrossRefGoogle Scholar
McCance, D. J., Campion, M. J., Clarkson, P. K., Chesters, P. M., Jenkins, D. & Singer, A. (1985). Prevalence of human papillomavirus type 16 DNA sequences in cervical intraepithelial neoplasia and invasive carcinoma of the cervix. British Journal of Obstetrics and Gynaecology 92, 1101–1105.CrossRefGoogle ScholarPubMed
Mendis, L. N., Best, J. M. & Banatvala, J. E. (1981). Class-specific antibodies (IgG and IgA) to membrane antigens of herpes simplex type 2 infected cells in patients with cervical dysplasia and neoplasia. International Journal of Cancer 27, 669–667.CrossRefGoogle ScholarPubMed
Mendis, L. N., Best, J. M., Senarath, L., Chiphangwi, J., Vestergaard, B. F. & Banatvala, J. E. (1981). A geographical study of antibodies to membrane antigens of HSV2 infected cells and HSV2 specific antibodies in patients with cervical cancer. International Journal of Cancer 28, 535–542.CrossRefGoogle ScholarPubMed
Nahmias, A. J. & Sawanabori, S. (1978). The genital herpes–cervical cancer hypothesis – 10 years later. Progress in Experimental Ttimor Research 21, 117–139.CrossRefGoogle ScholarPubMed
Pasca, A. S., Kummerlander, L., Pejtsik, B. & Pali, K. (1975). Herpes virus antibodies and antigens in patients with cervical anaplasia and in controls. Journal of the National Cancer Institute 55, 775–780.Google Scholar
Peltonen, R. (1975). Antibodies to herpesvirus hominis types 1 and 2 among women with neoplastic change of uterine cervix. Acta Obsletrica et Gynecologica Scandinavica 54, 369–372.CrossRefGoogle ScholarPubMed
Rawls, W. E., Adam, E. & Melnick, J. L. (1972). Geographical variation in the association of antibodies to herpes virus type 2 and carcinoma of the cervix. In Oncogenesis and Herpes Viruses, vol. 2 (ed. De Thé, G., Biggs, P. M. & Payne, L. N.), pp. 424–427. Lyon, France: IARC Scientific Publications.Google Scholar
Rawls, W. E. & Campione-Piccardo, J. (1981). Epidemiology of herpes simplex virus type 1 and type 2 infection. In The Human Herpes Viruses. An Interdisciplinary Perspective (ed. Nahmias, A. J., Dowdle, W. R. & Schinazi, R. F.), pp. 137–152. New York: Elsevier.Google Scholar
Rawls, W. E., Garfield, C. H., Seth, P. & Adam, E. (1976). Biological and epidemiologieal considerations of the role of herpes simplex virus tvpe 2 in cervical cancer. Cancer Research 36, 829–835.Google Scholar
Rawls, W. E., Lavery, C., Marrett, L. D., Clarke, E. A., Adam, E., Melnick, J. L., Best, J. M., Kraiselburd, E., Bendedet, L. J., Brenes, M. M., Quiroz, E. & Reeves, W. C. (1980). Comparison of risk factors for cervical cancer in different populations. International Journal of Cancer 37.537–546.CrossRefGoogle Scholar
Seth, P., Prakash, S. S., Ghosh, D. (1978). Antibodies to herpes simplex virus types 1 and 2 in patients with squamous cell carcinoma of uterine cervix in India. International Journal of Cancer 22, 708–714.CrossRefGoogle ScholarPubMed
Treharne, J. D., Darougar, S., Simmons, P. D. & Thin, R. N. (1978). Rapid diagnosis of chlamydial infection of the cervix. British Journal of Venereal Diseases 54, 403–408.Google ScholarPubMed
Vonka, V., Kanka, J., Hirsch, I., Zavadova, H., Kromar, M., Suchhankova, A., Rezacova, D., Bkoucek, B., Press, M., Domorazkova, E., Svoboda, B., Havrankova, A. & Jelinek, J. (1984). Prospective study on the relationship between cervical neoplasia and herpes simplex type-2 virus. II. Herpes simplex type-2 antibody presence in sera taken at enrolment. International Journal of Cancer 33, 61–66.CrossRefGoogle Scholar
Zur Hausen, H. (1982). Human genital cancer: synergism between two virus infections or synergism between a virus infection and initiating agents? Lancet ii, 1370–1372.Google Scholar