Hostname: page-component-76fb5796d-zzh7m Total loading time: 0 Render date: 2024-04-26T05:55:19.015Z Has data issue: false hasContentIssue false
  • English
  • Français

Chronic atrophic oral candidiasis among patients with diabetes mellitus – role of secretor status

Published online by Cambridge University Press:  15 May 2009

F. Z. Aly ,
C. C. Blackwell ,
D. A. C. MacKenzie ,
D. M. Weir ,
R. A. Elton ,
C. G. Cumming ,
J. A. Sofaer  and
B. F. Clarke
F. Z. Aly
Affiliation:
Department of Medical Microbiology, University of Edinburgh Medical School, Edinburgh EH8 9AG
C. C. Blackwell
Affiliation:
Department of Medical Microbiology, University of Edinburgh Medical School, Edinburgh EH8 9AG
D. A. C. MacKenzie
Affiliation:
Department of Medical Microbiology, University of Edinburgh Medical School, Edinburgh EH8 9AG
D. M. Weir
Affiliation:
Department of Medical Microbiology, University of Edinburgh Medical School, Edinburgh EH8 9AG
R. A. Elton
Affiliation:
Medical Statistics Unit, University of Edinburgh
C. G. Cumming
Affiliation:
Department of Oral Medicine and Oral Pathology, University of Edinburgh
J. A. Sofaer
Affiliation:
Department of Oral Medicine and Oral Pathology, University of Edinburgh
B. F. Clarke
Affiliation:
Department of Diabetes, Royal Infirmary, Edinburgh
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Non-diabetic individuals who are non-secretors of blood group antigens are prone to superficial infections by Candida albicans. In this study, 216 patients with diabetes mellitus who were denture wearers were examined for the presence or absence of denture stomatitis. There was an overall trend for non-secretors to be prone to denture stomatitis compared with secretors. Stepwise linear discriminant analysis was used to dissect the contribution of secretor status and other variables to the development of the disease. Secretor status was found to be a contributory factor among patients with non-insulin dependent diabetes but not among those with insulin-dependent diabetes. The possible reasons for this are discussed.

Type
Special Article
Information
Epidemiology & Infection , Volume 106 , Issue 2 , April 1991 , pp. 355 - 363
Copyright
Copyright © Cambridge University Press 1991

References

REFERENCES

1.Budtz-Jorgensen, E. The significance of C. albicans in denture stomatitis. Scand J Dent Res 1974; 82: 151–90.Google ScholarPubMed
2.Cawson, RA. Denture sore mouth and angular cheilitis. Oral candidiasis in adults. Br Dental J 1963; 155: 441–9.Google Scholar
3.Odds, FC. Factors that predispose the host to candidiasis. In: Candida and candidasis: A review and bibliography. 2nd ed.Baillière Tindall, 1988: 93–114.Google Scholar
4.Blackwell, CC. Genetic susceptibility to infectious agents. Proc Roy Coll Phys Edin 1989; 19: 129–35.Google Scholar
5.Thom, SM, Blackwell, CC, MacCallum, C et al. , Non-secretion of ABO blood group antigens and susceptibility to infection by Candida species. FEMS Microbiol Immunol 1989; 47: 401–6.CrossRefGoogle Scholar
6.Burford-Mason, AP, Welsby, JCP, Willoughby, JMT. Oral carriage of Candida albicans, ABO blood group and secretor status in healthy individuals. J Med Veter Mycol 1988; 26: 49–56.CrossRefGoogle Scholar
7.Blackwell, CC, Aly, FZM, James, VS et al. , Blood group, secretor status and oral carriage of yeasts among patients with diabetes mellitus. Diabetic Res 1989; 12: 101–4.Google ScholarPubMed
8.Mollison, PL. Blood transfusion in clinical medicine, 6th ed.Oxford: Blackwell, 1979; 414–82.Google Scholar
9.Milne, LJR. Fungi. In: Practical medical microbiology. 13th ed.Edinburgh: Churchill Livingstone, 1988: 675–99.Google Scholar
10.Halperin, V, Kolab, S, Jefferis, KR, Huddleston, SO, Robinson, HBG. The occurrence of Fordyce spots, benign migratory glossitis, median rhomboid glossitis and fissured tongue in 2478 dental patients. Oral Surg Oral Med Oral Pathol 1953; 6: 1072–7.CrossRefGoogle Scholar
11.McCarthy, FP. A clinical and pathologic study of oral disease. JAMA 1941; 16: 116.Google Scholar
12.Farman, AG. Atrophic lesions of the tongue: a prevalence study among 175 diabetic patients. J Oral Pathol 1976; 5: 255–64.CrossRefGoogle Scholar
13.Sharon, A, Ben-Ayreh, H, Etzhak, B, Yoram, K, Szargel, R, Gulman, D. Salivary composition in diabetic patients. J Oral Med 1985; 40: 23–6.Google ScholarPubMed
14.Davenport, JC. The oral distribution of Candida in denture stomatitis. Br Dent J 1970; 129: 151–6.CrossRefGoogle ScholarPubMed
15.Cawson, RA. Chronic oral candidiasis, denture stomatitis and chronic hyperplastic candidiasis. In: Winner, HI, Hurley, eds. Symposium on candidal infections. Edinburgh: Churchill Livingstone, 1964; 138–53.Google Scholar
16.Budtz-Jörgensen, E. An epidemiological study of yeasts in elderly denture wearers. Community Dent Oral Epidemiol 1975; 3: 115–9.CrossRefGoogle Scholar
17.Budtz-Jörgensen, E, Bertram, V. Denture stomatitis. I. The etiology in relation to trauma and infection. Acta Odontol Scand 1970; 28: 71–92.CrossRefGoogle ScholarPubMed
18.Neil, DJ. Symposium on denture sore mouth I. An etiology review. Dent Practit 1965; 16: 135–8.Google Scholar
19.Nyquist, G. Denture sore mouth. Acta Odont Scand 1952; 10: Suppl. 9.Google ScholarPubMed
20.Arendorf, TM, Walker, DM, Kingdom, RJ, Roll, JRS, Newcombe, RG. Tobacco smoking and denture wearing in oral candidal leukoplakia. Br Dent J 1983; 155: 340–3.CrossRefGoogle ScholarPubMed
21.Vogt, FC. The incidence of oral candidiasis with use of inhaled corticosteroid. Ann Allergy 1979; 43: 205–10.Google Scholar
22.Lamey, PJ. Secretor status, candidal carriage and candidal infection in patients with diabetes mellitus. J Oral Pathol 1988; 17: 354–7.CrossRefGoogle ScholarPubMed
23.Turrell, AJW. Aetiology of inflamed upper denture-bearing tissues. Br Dent J 1966; 120: 542–6.Google ScholarPubMed