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The changing HIV-1 genetic characteristics and transmitted drug resistance among recently infected population in Yunnan, China

  • M. Chen (a1) (a2), M. H. Jia (a1), Y. L. Ma (a1), H. B. Luo (a1), H. C. Chen (a1), C. J. Yang (a1), J. Dai (a1), L. Yang (a1), L. J. Dong (a1), R. Lu (a1), L. J. Song (a1), Y. Han (a1), J. Y. Lu (a1), A. K. L. Cheung (a2), Z. W. Chen (a2) and L. Lu (a1) (a3)...

Abstract

Multiple human immunodeficiency virus (HIV)-1 genotypes in China were first discovered in Yunnan Province before disseminating throughout the country. As the HIV-1 epidemic continues to expand in Yunnan, genetic characteristics and transmitted drug resistance (TDR) should be further investigated among the recently infected population. Among 2828 HIV-positive samples newly reported in the first quarter of 2014, 347 were identified as recent infections with BED-captured enzyme immunoassay (CEIA). Of them, 291 were successfully genotyped and identified as circulating recombinant form (CRF)08_BC (47.4%), unique recombinant forms (URFs) (18.2%), CRF01_AE (15.8%), CRF07_BC (14.4%), subtype C (2.7%), CRF55_01B (0.7%), subtype B (0.3%) and CRF64_BC (0.3%). CRF08_BC and CRF01_AE were the predominant genotypes among heterosexual and homosexual infections, respectively. CRF08_BC, URFs, CRF01_AE and CRF07_BC expanded with higher prevalence in central and eastern Yunnan. The recent common ancestor of CRF01_AE, CRF07_BC and CRF08_BC dated back to 1983.1, 1992.1 and 1989.5, respectively. The effective population sizes (EPS) for CRF01_AE and CRF07_BC increased exponentially during 1991–1999 and 1994–1999, respectively. The EPS for CRF08_BC underwent two exponential growth phases in 1994–1998 and 2001–2002. Lastly, TDR-associated mutations were identified in 1.8% of individuals. These findings not only enhance our understanding of HIV-1 evolution in Yunnan but also have implications for vaccine design and patient management strategies.

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Copyright

Corresponding author

Author for correspondence: Lin Lu, E-mail: linluyn@126.com

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These authors contributed equally to this work.

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References

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Epidemiology & Infection
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