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Cell surface hydrophobicity and adherence to extra–cellular matrix proteins in two collections of methicillin–resistant Staphylococcus aureus

Published online by Cambridge University Press:  15 May 2009

R. G. A. Cree ,
P. Aleljung ,
M. Paulsson ,
W. Witte ,
W. C. Noble ,
A. Ljungh  and
T. Wadström
R. G. A. Cree
Affiliation:
Department of Microbial Diseases, St John's Institute of Dermatology, St Thomas' Hospital, London SE1 7EH, UK
P. Aleljung
Affiliation:
Department of Medical Microbiology, Lund University, S-223 63, Lund, Sweden
M. Paulsson
Affiliation:
Department of Medical Microbiology, Lund University, S-223 63, Lund, Sweden
W. Witte
Affiliation:
Bundesgesundheitsamt, Robert von Ostertag Institut, Bereich Wernigerode D-0-3700 Wernigerode, Germany
W. C. Noble*
Affiliation:
Department of Microbial Diseases, St John's Institute of Dermatology, St Thomas' Hospital, London SE1 7EH, UK
A. Ljungh
Affiliation:
Department of Medical Microbiology, Lund University, S-223 63, Lund, Sweden
T. Wadström
Affiliation:
Department of Medical Microbiology, Lund University, S-223 63, Lund, Sweden
*
*Professor W.C.Noble, Department of Microbial Diseases. St John's Institute of Dermatology. St Thomas' Hospital. London SE1 7EH
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Summary

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Non-specific and specific mechanisms of adherence have been examined in two collections of methicillin–resistant Staphylococcus aureus (MRSA). Determination of hydrophobicity by salt aggregation, hydrophobicity indices and of adherence to the extra–cellular matrix proteins fibronectin, vitronectin, laminin and collagen type 1 have failed to reveal any correlation with phage-type, plasmid profile or antibiogram. Further, the strain collections, made over a period of years in two countries, differ markedly in their adherence characteristics; MRSA are heterogeneous in this respect. Such heterogeneity may explain the polarization of views on the epidemicity or ‘virulence’ of MRSA. With the exception of adherence to collagen a small group of methicillin sensitive S. aureus had characteristics intermediate between the two groups of MRSA.

Type
Research Article
Information
Epidemiology & Infection , Volume 112 , Issue 2 , April 1994 , pp. 307 - 314
Copyright
Copyright © Cambridge University Press 1994

References

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