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Bacteriostasis of Escherichia coli by milk. VI. The in-vitro bacteriostatic property of Gambian mothers' breast milk in relation to the in-vivo protection of their infants against diarrhoeal disease

Published online by Cambridge University Press:  19 October 2009

M. G. M. Rowland ,
T. J. Cole ,
Maura Tully ,
Jean M. Dolby  and
Pauline Honour
M. G. M. Rowland
Affiliation:
Medical Research Council Dunn Nutrition Unit, Keneba, The Gambia, and Milton Road, Cambridge CB4 1XJ
T. J. Cole
Affiliation:
Medical Research Council Dunn Nutrition Unit, Keneba, The Gambia, and Milton Road, Cambridge CB4 1XJ
Maura Tully
Affiliation:
Medical Research Council Dunn Nutrition Unit, Keneba, The Gambia, and Milton Road, Cambridge CB4 1XJ
Jean M. Dolby
Affiliation:
Clinical Research Centre, Harrow, Middlesex HA1 3UJ
Pauline Honour
Affiliation:
Clinical Research Centre, Harrow, Middlesex HA1 3UJ
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A one-year field-study has been carried out in a diarrhoea-endemic area in West Africa to determine the relationship between the bacteriostatic activity of fresh human milk for Escherichia coli in vitro and freedom from diarrhoea of the infant recipients of the milk. The specific contribution of E. coli gastroenteritis to gastrointestinal diseases of infants in general is not known, nor is its particular role in the Gambian infants studied. During the study period, however, both enteropathogenic and toxigenic strains of E. coli were isolated.

The incidence of diarrhoea in Gambian infants of seven age-groups from 2 days to 12 months was not significantly correlated with the bacteriostatic activity of milk. This was due rather to absence of diarrhoea in babies fed on low-activity milk than illness in those receiving highly bacteriostatic milk. Indeed, very active milk appeared to protect recipients almost completely, including seven babies of over 3 months of age, five of them during the rainy season, when the risk was high. Babies receiving lower-activity milk experienced more diarrhoea. In a situation where diarrhoeal disease is multifactorial, field evaluation of the protective action by one antibacterial property of milk is difficult. A better understanding of in vivo protection is important, and the factors which have to be taken into account are discussed.

Type
Research Article
Information
Journal of Hygiene , Volume 85 , Issue 3 , December 1980 , pp. 405 - 413
Copyright
Copyright © Cambridge University Press 1980

References

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